Corrigendum to 'Allergic Conjunctivitis-induced Retinal Inflammation Promotes Myopia Progression' [EBioMedicine 28 (2018) 274–286]
| Autor: | Peng-Tai Tien, Hui Ju Lin, Chao-Jen Lin, Chang-Ching Wei, Hsuan-Ju Chen, Ching-Yao Chang, Lei Wan, Hsing-Yi Chang, Chih Sheng Chen, Yung-Jen Kung, Yong-San Huang |
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| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Male
genetic structures Ovalbumin Inflammation Allergic conjunctivitis Models Biological Allergic rhinitis General Biochemistry Genetics and Molecular Biology Retina Cohort Studies Cornea chemistry.chemical_compound Risk Factors medicine Myopia Animals Humans Child Atopic dermatitis Population-based study Conjunctivitis Allergic Demography Proportional Hazards Models business.industry Interleukin-6 Tumor Necrosis Factor-alpha Incidence Retinal Epithelial Cells General Medicine medicine.disease eye diseases Asthma chemistry Rats Inbred Lew Immunology Disease Progression Female medicine.symptom business Corrigendum Research Paper |
| Zdroj: | EBioMedicine |
| ISSN: | 2352-3964 |
| Popis: | Myopia is a highly prevalent eye disease. There is limited information suggesting a relationship between myopia and inflammation. We found children with allergic conjunctivitis (AC) had the highest adjusted odds ratio (1.75, 95% confidence interval [CI], 1.72–1.77) for myopia among the four allergic diseases. A cohort study was conducted and confirmed that children with AC had a higher incidence and subsequent risk of myopia (hazard ratio 2.35, 95%CI 2.29–2.40) compared to those without AC. Lower refractive error and longer axial length were observed in an AC animal model. Myopia progression was enhanced by tumor necrosis factor (TNF)-α or interleukin (IL)-6 administration, two cytokines secreted by mast cell degranulation. The TNF-α or IL-6 weakened the tight junction formed by corneal epithelial (CEP) cells and inflammatory cytokines across the layer of CEP cells, which increased the levels of TNF-α, IL-6, and IL-8 secreted by retinal pigment epithelial cells. The expression levels of TNF-α, IL-6, IL-8, monocyte chemoattractant protein-1, and nuclear factor kappa B were up-regulated in eyes with AC, whereas IL-10 and the inhibitor of kappa B were down-regulated. In conclusion, the experimental findings in mice corroborate the epidemiological data showing that allergic inflammation influences the development of myopia. Highlights • Asthma, allergic rhinitis, atopic dermatitis, and allergic conjunctivitis are risk factors for myopia. • Children with allergic conjunctivitis had the highest adjusted odds ratio for myopia. • Up-regulation of allergic inflammation promotes the progression of myopia in the animal model. Myopia is a major cause of visual impairment and has a huge impact on public healthcare systems and economies worldwide. The relationship between myopia and inflammation has seldom been discussed. We demonstrated that allergic inflammation promotes myopia progression. |
| Databáze: | OpenAIRE |
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