Functional assessment of cryopreserved human aortas for pharmaceutical research
| Autor: | S. Pértega Díaz, R.O. Fernández Mallo, María Esther Rendal Vázquez, M.V. Martínez Santos, P. Filgueira Fernández, R Segura Iglesias, C. Andión Núñez, T Bermúdez González, J Sánchez Ibáñez, G Matheu Capó, M. Rodríguez Cabarcos |
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| Rok vydání: | 2004 |
| Předmět: |
Male
Nitroprusside medicine.medical_specialty Endothelium Biomedical Engineering Aorta Thoracic In Vitro Techniques Cryopreservation Biomaterials Andrology Norepinephrine Transplant surgery medicine.artery Humans Medicine Pharmaceutical sciences Transplantation business.industry Cell Biology Middle Aged Acetylcholine Surgery Vasodilation medicine.anatomical_structure Vasoconstriction Descending aorta cardiovascular system Female Endothelium Vascular Tissue Preservation business |
| Zdroj: | Cell and Tissue Banking. 5:119-123 |
| ISSN: | 1389-9333 |
| Popis: | We evaluated the impact of standard cryopreservation on functional properties of human aortic homografts. From seven human donors, the thoracic descending aorta was obtained. Effects of cryopreservation on contractibility and endothelium function were tested. After cryopreservation no endothelium-dependent or endothelium-independent relaxation was found and the contractibility was strongly affected. Arteries showed no function and loss of endothelial integrity after cryopreservation and thawing. |
| Databáze: | OpenAIRE |
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