Low dose sulprostone for termination of second and third trimester pregnancies
| Autor: | S.A. Scherjon, Marjon A. de Boer, Nicolette van Gemund, H. H. H. Kanhai |
|---|---|
| Přispěvatelé: | Obstetrics and gynaecology, AII - Infectious diseases, Amsterdam Reproduction & Development (AR&D) |
| Jazyk: | angličtina |
| Rok vydání: | 2001 |
| Předmět: |
medicine.medical_specialty
Time Factors medicine.medical_treatment Gestational Age Dinoprostone Congenital Abnormalities Uterine Rupture Pregnancy medicine Humans Caesarean section Advanced maternal age Labor Induced Abortifacient reproductive and urinary physiology Retrospective Studies Gynecology Abortifacient Agents Nonsteroidal business.industry Vaginal delivery Obstetrics Postpartum Hemorrhage Uterus Obstetrics and Gynecology Gestational age Abortion Induced medicine.disease Therapeutic abortion Uterine rupture Parity Reproductive Medicine embryonic structures Linear Models Female business |
| Zdroj: | De Boer, M A, Van Gemund, N, Scherjon, S A & Kanhai, H H H 2001, ' Low dose sulprostone for termination of second and third trimester pregnancies ', European Journal of Obstetrics and Gynecology and Reproductive Biology, vol. 99, no. 2, pp. 244-248 . https://doi.org/10.1016/S0301-2115(01)00406-7 European Journal of Obstetrics and Gynecology and Reproductive Biology, 99(2), 244-248. Elsevier Ireland Ltd |
| ISSN: | 0301-2115 |
| Popis: | Objective: The purpose of this study is to assess the effectiveness and safety of sulprostone (nalador®) for labour induction in the event of foetal death or foetal malformations. Study design: Retrospective analysis of 284 women with intrauterine foetal death (n=137), or foetal abnormalities (n=147), who underwent labour induction with sulprostone in a continuous dose of 1 μg/min intravenously. Results: All but three women had a successful vaginal delivery. The median induction–expulsion interval was significantly shorter (12 h) in the foetal death group compared to the foetal malformation group (25 h). Two uterine ruptures were recorded, one in a woman with a uterine anomaly, and one in a woman with a previous caesarean section. There were no other complications. Gestational age had a significant influence on spontaneous expulsion of the placenta: before 24 weeks 55%, and after 24 weeks 82% spontaneous expulsion. For the chance of a neonate born with signs of life, parity was the only significant determinant. Conclusions: The use of intravenous sulprostone in a low continuous dose is both effective and safe. In addition, this study does not support former opinions that smoking and advanced maternal age are contraindications. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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