Tissue-Specific Molecular Markers and Heterogeneity in Type 2 Innate Lymphoid Cells
| Autor: | Blanca E. Ruiz-Medina, Enrique Olguín-Martínez, Paula Licona-Limón |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Adipose Tissue
White Immunology Helminthiasis Receptors Cell Surface Review Biology Immunophenotyping ILC2 Mice Immune system Immunology and Allergy Cytotoxic T cell Tissue specific Animals Homeostasis Humans Lung Tissue homeostasis Skin Inflammation marker Stem Cell Factor function Innate lymphoid cell Histocompatibility Antigens Class II tissue Nutrients RC581-607 Antigens Differentiation Lymphocyte Subsets Intestines Proto-Oncogene Proteins c-kit Organ Specificity Cytokines Identification (biology) Immunologic diseases. Allergy heterogeneity Function (biology) |
| Zdroj: | Frontiers in Immunology Frontiers in Immunology, Vol 12 (2021) |
| ISSN: | 1664-3224 |
| Popis: | Innate lymphoid cells (ILCs) are the most recently described group of lymphoid subpopulations. These tissue-resident cells display a heterogeneity resembling that observed on different groups of T cells, hence their categorization as cytotoxic NK cells and helper ILCs type 1, 2 and 3. Each one of these groups is highly diverse and expresses different markers in a context-dependent manner. Type 2 innate lymphoid cells (ILC2s) are activated in response to helminth parasites and regulate the immune response. They are involved in the etiology of diseases associated with allergic responses as well as in the maintenance of tissue homeostasis. Markers associated with their identification differ depending on the tissue and model used, making the study and understanding of these cells a cumbersome task. This review compiles evidence for the heterogeneity of ILC2s as well as discussion and analyses of molecular markers associated with their identity, function, tissue-dependent expression, and how these markers contribute to the interaction of ILC2s with specific microenvironments to maintain homeostasis or respond to pathogenic challenges. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|