Selective restoration of immunosuppressive effect of cytotoxic agents by thymopoietin fragments
| Autor: | Karoly Lapis, Laszlo Denes, L Szporny, Béla Szende, Gyorgy Hajos |
|---|---|
| Rok vydání: | 1990 |
| Předmět: |
Male
Cancer Research Vincristine medicine.medical_specialty Erythrocytes Combination therapy Cyclophosphamide medicine.medical_treatment T-Lymphocytes Immunology Thymopoietins Antineoplastic Agents Pharmacology Biology Mice Immune system Phagocytosis Internal medicine medicine Immunology and Allergy Cytotoxic T cell Animals Thymopoietin Chemotherapy Sheep Peptide Fragments Endocrinology Methotrexate Oncology Antibody Formation biology.protein Cisplatin Immunosuppressive Agents medicine.drug |
| Zdroj: | Cancer immunology, immunotherapy : CII. 32(1) |
| ISSN: | 0340-7004 |
| Popis: | Swiss male mice were immunosuppressed by cyclophosphamide, cisplatinum, vincristine and methotrexate. The ability of the thymopoietin (TP) fragments TP-3, TP-4 and TP-5 to restore antibody production and phagocytosis was studied. Impaired antibody production after vincristine treatment was partially or totally restored by TP-3, TP-4 or TP-5. Only TP-3 or TP-5 interfered with the antibody-production-damaging effect of cisplatinum. The same effect of methotrexate could not be influenced by any of the TP fragments. The phagocytic capacity of peritoneal macrophages was reduced by vincristine, methotrexate and cyclophosphamide treatment. In this respect, TP-3 protected the function of macrophages against vincristine and cyclophosphamide treatment. TP-4 was active in the case of damage caused by vincristine and methotrexate, and TP-5 interfered with the phagocytosis-inhibiting effect of methotrexate. Each TP fragment seems to have a specific target orientation within the immune system. This also means that the proper TP fragment should always be chosen for combination therapy with various types of cytotoxic drugs. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink