Hepatoprotective effect of Raspberry ketone and white tea against acrylamide-induced toxicity in rats
| Autor: | Soha M. Hamdy, Diaa Massoud, Zakaria El-Khayat, Abdel Razik H. Farrag, Mervat M El-Sayed, Ola N. Sayed |
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| Rok vydání: | 2020 |
| Předmět: |
Male
Adult male Health Toxicology and Mutagenesis Raspberry ketone 010501 environmental sciences Pharmacology Toxicology 01 natural sciences Antioxidants Superoxide dismutase 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Animals Rats Wistar 0105 earth and related environmental sciences Acrylamide Chemical Health and Safety Tea Adiponectin biology Plant Extracts Public Health Environmental and Occupational Health General Medicine Butanones Rats Oxidative Stress Liver chemistry Toxicity biology.protein Chemical and Drug Induced Liver Injury 030217 neurology & neurosurgery |
| Zdroj: | Drug and Chemical Toxicology. 45:722-730 |
| ISSN: | 1525-6014 0148-0545 |
| DOI: | 10.1080/01480545.2020.1772279 |
| Popis: | The current investigation was accomplished to evaluate the hepatoprotective effect of White tea and Raspberry Ketone against toxicity induced by acrylamide in rats. Sixty adult male rats were divided randomly into group (I) control; group (II) rats received RK with dose (6 mg/kg/day); Group III: rats received 5 ml of WT extract/kg/day; Group IV rats received AA (5 mg/kg/day); Group V: rats administrated with both AA (5 mg/kg/day) and RK (6 mg/kg/day) and Group VI: rats administrated AA (5 mg/kg/day) and 5 ml of WT extract/kg/day. The biochemical assays exhibited a significant increase in serum levels of Adiponectin, AST, ALT, ALP of the group treated with acrylamide if compared to the control group and an improvement in their levels of groups V and VI. The histopathological and immunohistochemical findings confirm the biochemical observations. In conclusion, the present investigation proved that the supplementation of WT and RK enhanced the liver histology, immunohistochemistry and biochemistry against the oxidative stress induced by acrylamide. |
| Databáze: | OpenAIRE |
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