Histological comparison of malignant epithelioid mesothelioma in young and adult cattle
| Autor: | Koichi Kadota, Ayako Fujimoto, Osamu Mikami, Morihiro Saito, Yuuto Kawashima, Yoshiharu Ishikawa |
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| Rok vydání: | 2021 |
| Předmět: |
Epithelioid mesothelioma
Mesothelioma Pathology medicine.medical_specialty Lung Neoplasms 040301 veterinary sciences Cattle Diseases Biology Malignant epithelioid mesothelioma 0403 veterinary science Diagnosis Differential 03 medical and health sciences Cytokeratin medicine Biomarkers Tumor Animals 030304 developmental biology 0303 health sciences Fetus General Veterinary collagen production Mesothelioma Malignant cytokeratin 7 Histology 04 agricultural and veterinary sciences medicine.disease Note Immunohistochemistry cattle pleomorphic mesothelioma Female epithelioid mesothelioma Mesothelial Cell |
| Zdroj: | The Journal of Veterinary Medical Science |
| ISSN: | 1347-7439 |
| Popis: | The histology and immunohistochemistry of pleomorphic and conventional epithelioid mesotheliomas were examined. The former was detected in two young calves aged 2 and 4 months and was characterized by pleomorphic and atypical cells with decreased expression of cytokeratin 7 (CK7). In contrast, the latter was found in a 31-month-old heifer, consisting of tumor cells uniform in size and shape with CK7 expression in nearly all cells. Production of collagen by tumor cells was demonstrated in both histological types, and was considered to be characteristic of bovine epithelioid mesothelioma. Pleomorphic mesothelioma is far more pleomorphic and mitotically active than conventional mesothelioma, and its normal counterpart may be immature mesothelial cells with high proliferation potential, which exist in fetal life and early calfhood. |
| Databáze: | OpenAIRE |
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