| Přispěvatelé: |
Cozzi, Giorgio, Cortellazzo Wiel, Luisa, Amaddeo, Alessandro, Gatto, Antonio, Giangreco, Manuela, Klein-Kremer, Adi, Bosis, Samantha, Silvagni, Davide, Debbia, Carla, Nanni, Laura, Chiappa, Sara, Minute, Marta, Corsini, Ilaria, Morabito, Giuliana, Gortan, Anna Jolanda, Colombo, Marco, Marchetti, Federico, Garelli, Davide, Piffer, Arianna, Cardinale, Fabio, Levy, Nitai, Curatola, Antonietta, Gojsina, Bojana, Basu, Suvradeep, Barbi, Egidio, Sovtic, Aleksandar |
| Popis: |
BackgroundBronchiolitis is the leading acute respiratory tract infection in infants during the winter season. Since the beginning of the SARS-CoV-2 pandemic, a reduction in the number of bronchiolitis diagnoses has been registered.ObjectiveThe present study aimed to describe the incidence and clinical features of bronchiolitis during the 2020–2021 winter season in a large cohort of children in Europe and Israel, and to clarify the role of SARS-CoV-2.Setting, patients, interventionsWe conducted a multicentre observational cross-sectional study in 23 paediatric emergency departments in Europe and Israel. Clinical and demographic data about all the cases of infants diagnosed with bronchiolitis from 1 October 2020 to 30 April 2021 were collected. For each enrolled patient, diagnostic tests, treatments and outcomes were reported.Main outcome measuresThe main outcome was the prevalence of SARS-CoV-2-positive bronchiolitis.ResultsThree hundred and fourteen infants received a diagnosis of bronchiolitis during the study period. Among 535 infants who tested positive for SARS-CoV-2, 16 (3%) had bronchiolitis. Median age, male sex predominance, weight, history of prematurity and presence of comorbidities did not differ between the SARS-CoV-2-positive and SARS-CoV-2-negative groups. Rhinovirus was the most common involved pathogen, while respiratory syncytial virus (RSV) was detected in one case. SARS-CoV-2 bronchiolitis had a mild clinical course, with one patient receiving oxygen supplementation and none requiring paediatric or neonatal intensive care unit admission.ConclusionsDuring the SARS-CoV-2 pandemic, a marked decrease in the number of bronchiolitis diagnoses and the disappearance of the RSV winter epidemic were observed. SARS-CoV-2-related bronchiolitis was rare and mostly displayed a mild clinical course. |
