Postischemic hypoperfusion during unilateral lung reperfusion in vivo
| Autor: | Robert J. Gilroy, K. A. Overholser, N. A. Pou, M. J. Bhatte, Nancy Wickersham, James E. Loyd |
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| Rok vydání: | 1993 |
| Předmět: |
Pulmonary and Respiratory Medicine
medicine.medical_specialty Pathology Radioisotope Dilution Technique Time Factors Ischemia Hemodynamics Vascular permeability Models Biological Capillary Permeability Internal medicine medicine Animals Lung Sheep business.industry Respiratory disease Blood flow Organ Size respiratory system medicine.disease Microspheres respiratory tract diseases Disease Models Animal medicine.anatomical_structure Reperfusion Injury Cardiology Vascular resistance Lymph business Reperfusion injury |
| Zdroj: | The American review of respiratory disease. 147(2) |
| ISSN: | 0003-0805 |
| Popis: | The incomplete restoration of blood flow during reperfusion may amplify injury by prolonging ischemia; this "no-reflow" has been studied extensively in systemic organs. Our goal was to examine lung blood flow and microvascular function, specifically to determine whether blood flow is altered during lung reperfusion injury in vivo. In a unilateral lung model of ischemia-reperfusion in awake sheep, we measured pulmonary vascular resistance in each lung by radiolabeled microspheres. Measurements were made before 14 h of ischemia and again 4 h after reperfusion. Vascular resistance in the reperfused lung increased 3-fold (9.64 +/- 0.85 to 27.04 +/- 4.73 cm H2O/L/min) during reperfusion. The increase in vascular resistance in the reperfused lung fully accounted for the small increase in overall pulmonary vascular resistance (4.04 +/- 0.26 to 5.52 +/- 0.70 cm H2O/L/min). Microvascular permeability in the reperfused lung increased 52% more than in the contralateral lung, measured by an improved indicator dilution method with additional markers sensitive to surface area (butanediol). We conclude that changes in vascular resistance and microvascular function occur during lung reperfusion injury in vivo. The demonstration that postischemic hypoperfusion occurs during lung reperfusion in vivo suggests possible new avenues of approach to related clinical disorders. |
| Databáze: | OpenAIRE |
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