| Autor: |
Thomas Le Bihan, Cathryn H.S. Driver, Thomas Ebenhan, Nathalie Le Bris, Jan Rijn Zeevaart, Raphael Tripier |
| Rok vydání: |
2020 |
| Popis: |
In the aim to design small molecules capable of binding in vivo to albumin to form bioconjugates, a second generation GluCAB derivative(Glucose-Chelator-Albumin Bioconjugate) has been synthesized and studied for in vivo 64Cu-PET/CT imaging in breast cancer mice models together with its first-generation analogue. This series of radioligands - also capable of complexing therapeutic isotopes and therefore classified as theranostic agents - are working on the principle of tumor targeting through the Enhanced Permeability and Retention (EPR) effect as well as glucose metabolism. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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