Rapid metabolic shifts occur during the transition between hunger and satiety in Drosophila melanogaster
| Autor: | Jasmine Winzeler, Jenna L. Persons, Morteza Khabiri, Johan Mosquera, Daniel Wilinski, Kristina J. Holme, Monica Dus, Alla Karnovsky, Peter L. Freddolino, William L. Duren, Jason M. Kinchen |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Hunger Science General Physics and Astronomy Context (language use) 02 engineering and technology Satiation General Biochemistry Genetics and Molecular Biology Article 03 medical and health sciences chemistry.chemical_compound Eating Internal medicine medicine Animals Humans Metabolomics Obesity Sugar lcsh:Science Multidisciplinary biology Transition (genetics) Dietary sugar digestive oral and skin physiology Brain General Chemistry Metabolism Fasting 021001 nanoscience & nanotechnology biology.organism_classification Diet Citric acid cycle 030104 developmental biology Endocrinology Drosophila melanogaster chemistry Metabolome Drosophila lcsh:Q 0210 nano-technology Kynurenine Metabolic Networks and Pathways Software |
| Zdroj: | Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019) Nature Communications |
| ISSN: | 2041-1723 |
| Popis: | Metabolites are active controllers of cellular physiology, but their role in complex behaviors is less clear. Here we report metabolic changes that occur during the transition between hunger and satiety in Drosophila melanogaster. To analyze these data in the context of fruit fly metabolic networks, we developed Flyscape, an open-access tool. We show that in response to eating, metabolic profiles change in quick, but distinct ways in the heads and bodies. Consumption of a high sugar diet dulls the metabolic and behavioral differences between the fasted and fed state, and reshapes the way nutrients are utilized upon eating. Specifically, we found that high dietary sugar increases TCA cycle activity, alters neurochemicals, and depletes 1-carbon metabolism and brain health metabolites N-acetyl-aspartate and kynurenine. Together, our work identifies the metabolic transitions that occur during hunger and satiation, and provides a platform to study the role of metabolites and diet in complex behavior. The relationship between metabolomic and behavioral changes is not well understood. Here, the authors analyze metabolome changes in D. melanogaster heads and bodies during hunger and satiety, and develop the Flyscape tool to visualize the resulting metabolic networks and integrate them with other omics data. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|