Image-guided percutaneous cryoablation of T1b renal cell carcinomas in patients with comorbidities
Autor: | Shunichi Sadaoka, Keitaro Enoki, Kenji Motohashi, Yoshihiko Kameoka, Huruki Sekiguchi, Kanichiro Shimizu, Takafumi Yanagisawa, Akira Baba, Jun Miki |
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Rok vydání: | 2021 |
Předmět: |
medicine.medical_specialty
business.industry medicine.medical_treatment Urology Renal function Comorbidity Odds ratio urologic and male genital diseases medicine.disease Cryosurgery Kidney Neoplasms Confidence interval Metastasis Radiation therapy Treatment Outcome Renal cell carcinoma Humans Medicine Radiology Nuclear Medicine and imaging Risk factor Stage (cooking) business Carcinoma Renal Cell Retrospective Studies |
Zdroj: | Japanese Journal of Radiology. 39:1213-1222 |
ISSN: | 1867-108X 1867-1071 |
DOI: | 10.1007/s11604-021-01168-8 |
Popis: | To investigate the influence of comorbidities and tumor characteristics on outcomes following percutaneous cryoablation (PCA) of T1b renal cell carcinoma (RCC). Age-adjusted Charlson comorbidity index (ACCI); standardized system for quantitating renal tumor size, location, and depth (RENAL nephrometry score [RNS]); and local tumor control and survival were retrospectively investigated in 28 patients who underwent PCA for stage T1b RCC. Risk factors for elevated serum creatinine levels were also investigated. Complete ablation was obtained in 27 of 28 patients. Two cases of metastasis were observed; one patient died 12 months after PCA. Overall survival at 5 years was 79.1%, with a mean follow-up of 42.0 ± 16.0 months. Local tumor control was not correlated with the ACCI and RNS. Worsening renal function 3 months after PCA was observed in ten patients, and it correlated with the presence of single kidneys (7/28 patients; p = 0.023). Significant worsening of renal function continued until 1 year after PCA (p = 0.013). Having a single kidney was a risk factor for worsened renal function after PCA (odds ratio, 8.00; 95% confidence interval 1.170–54.724). PCA for T1b RCC confers positive local tumor control regardless of comorbidities and tumor characteristics. |
Databáze: | OpenAIRE |
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