Triple therapy of initial high-dose interferon with ribavirin and amantadine for patients with chronic hepatitis C
| Autor: | Eijiro Hayashi, Hirayuki Enomoto, Hiroyuki Ogawa, Toshikazu Hada, Hirokazu Uyama, Norio Hayashi, Yorihide Okuda, Kenya Yoshida, Mitsunari Yamamoto, Hideji Nakamura |
|---|---|
| Rok vydání: | 2007 |
| Předmět: |
medicine.medical_specialty
Hepatology Combination therapy business.industry Ribavirin Hepatitis C virus Amantadine virus diseases medicine.disease_cause Virology Gastroenterology digestive system diseases chemistry.chemical_compound Infectious Diseases chemistry Chronic hepatitis Interferon Oral administration Internal medicine medicine business Viral load medicine.drug |
| Zdroj: | Hepatology Research. 37:325-330 |
| ISSN: | 1872-034X 1386-6346 |
| Popis: | Aims: We previously reported the potential effect of combination therapy of an initial high-dose interferon (IFN) and amantadine on the eradication of HCV-RNA in patients with chronic hepatitis C. The additive effects of amantadine on interferon and ribavirin combination therapy remain controversial. In this study we investigated the efficacy of initial high-dose IFN with ribavirin and amantadine on the virological response in patients with chronic hepatitis C with a high viral load of genotype 1b. Methods: Twenty-two patients with high viral loads of genotype 1b hepatitis C virus were enrolled in this pilot study. Patients were administered IFN-beta for four weeks and then IFN-alpha2b for 22 weeks with daily oral administration of ribavirin and amantadine. Results: A sustained virological response (SVR) was shown in 31.8% (seven of 22 patients). With the naive patients, the SVR rate was 21.4% (three of 14 patients). In patients who could not eradicate HCV-RNA by previous IFN monotherapy, the SVR rate was 50% (four of eight patients). Conclusion: Triple therapy with an initial high dose of IFN with ribavirin and amantadine may be effective, especially for chronic hepatitis C IFN-retreatment patients with a high viral load of genotype 1b. |
| Databáze: | OpenAIRE |
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