A quantitative genetic approach towards volatile anesthetic mechanisms in C. elegans

Autor:	B van Swinderen, C M Crowder, Alex Galifianakis
Rok vydání:	1999
Předmět:	Genetics Positional cloning Receptors Drug Congenic Locus (genetics) General Medicine Quantitative genetics Quantitative trait locus Heritability Biology Toxicology Gene mapping Expression quantitative trait loci Anesthetics Inhalation Animals Humans Caenorhabditis elegans Halothane
Zdroj:	Toxicology letters.
ISSN:	0378-4274
Popis:	Quantitative genetics is the study of the heritability of continuous traits such as height or IQ. Quantitative trait loci (QTLs) represent the genes that are responsible for these quantitative traits. Sensitivity to the volatile anesthetic halothane is a genetically controlled quantitative trait in the nematode C. elegans. The QTLs that are responsible for the 12-fold range in halothane EC50 in these strains map to a few places with at least one major effect locus on chromosome V. Congenic strains for chromosome V confirmed these loci and offer the means to finely map them for positional cloning.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6746d30bea82503fe14438f4d773b25f https://pubmed.ncbi.nlm.nih.gov/10049158 Zobrazit plný text záznamu Full Text from ScienceDirect