Ovalbumin is more immunogenic when introduced into brain or cerebrospinal fluid than into extracerebral sites
| Autor: | Leslie B. Gordon, Paul M. Knopf, Helen F. Cserr |
|---|---|
| Rok vydání: | 1992 |
| Předmět: |
Male
Pathology medicine.medical_specialty Ovalbumin Freund's Adjuvant Immunology Central nervous system Spleen Blood–brain barrier Antibodies Cerebral Ventricles Injections Cerebrospinal fluid Antigen medicine Animals Immunology and Allergy Administration Intranasal Cerebrospinal Fluid biology Foot business.industry Immunogenicity Brain Rats Inbred Strains Rats Drug Combinations Blood medicine.anatomical_structure Neurology Injections Intravenous biology.protein Immunization Neurology (clinical) Caudate Nucleus Antibody business |
| Zdroj: | Journal of Neuroimmunology. 40:81-87 |
| ISSN: | 0165-5728 |
| DOI: | 10.1016/0165-5728(92)90215-7 |
| Popis: | The magnitudes of serum antibody responses to ovalbumin have been compared following immunization via cerebral or extracerebral sites in Sprague-Dawley rats. In central nervous system (CNS)-immunized rats, conditions were designed to ensure normal brain barrier permeability. Extracerebral immunization was via the footpad or along pathways of antigen outflow from the CNS. The relative immunogenicity of different injection sites is: CSF greater than brain tissue greater than extracerebral sites. Enhancement of the antibody response to CNS-administered antigen appears to depend on events initiated within the CNS, since ovalbumin injected into blood (which reaches the spleen) or nasal submucosa (which drains to cervical nodes) fails to elicit a similar response. |
| Databáze: | OpenAIRE |
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