Course of illness in a sample of 265 patients with first-episode psychosis—Five-year follow-up of the Danish OPUS trial
| Autor: | Mette Bertelsen, Torben Østergaard Christensen, Lone Petersen, Johan Øhlenschlæger, Phuong le Quach, Pia Jeppesen, Anne Thorup, Per E. Jørgensen, Merete Nordentoft, Gertrud Krarup |
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| Rok vydání: | 2009 |
| Předmět: |
Adult
Male medicine.medical_specialty Psychosis Substance-Related Disorders Denmark Comorbidity Patient Readmission Danish Young Adult medicine Humans Longitudinal Studies Risk factor Prospective cohort study Psychiatry Biological Psychiatry Psychiatric Status Rating Scales First episode Public health Socialization Social environment medicine.disease Combined Modality Therapy Mental health Community Mental Health Services language.human_language Psychiatry and Mental health Psychotic Disorders Schizophrenia language Family Therapy Female Schizophrenic Psychology Psychology Case Management |
| Zdroj: | Schizophrenia Research. 107:173-178 |
| ISSN: | 0920-9964 |
| DOI: | 10.1016/j.schres.2008.09.018 |
| Popis: | There is an ongoing debate as to whether psychosis is a progressively deteriorating illness or one of progressive amelioration. This paper aims at investigating the rate of recovery and institutionalization and predicting a continuous illness course in a descriptive prospective study of a sub-sample of the OPUS trial of 265 first-episode psychotic patients after five years. Recovery, defined as no psychotic or negative symptoms, living independently, GAF ( f ) > 59, working or studying, was reached for 18% after five years, whereas 13% were institutionalized either at hospital or supported housing after five years. Male gender (OR 1.9, 95% CI 1.06 to 3.23), premorbid social functioning (OR 1.2, 95% CI 1.01 to 1.33), psychotic symptoms (OR 1.3, 95% CI 1.07 to 1.66), and negative symptoms (OR 1.3, 95% CI 1.01 to 1.67) were found to predict a continuous illness course at five-year follow-up. Rates of recovery and institutionalization contradict the assumption that the illness deteriorates progressively, since no changes in the rates are seen from two to five years. |
| Databáze: | OpenAIRE |
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