Mechanoreciprocity in cell migration

Autor: Peter Friedl, Sjoerd van Helvert, Cornelis Storm
Přispěvatelé: Soft Matter and Biological Physics, Institute for Complex Molecular Systems
Jazyk: angličtina
Rok vydání: 2018
Předmět:
0301 basic medicine
Cell physiology
Mechanotransduction
Cancer development and immune defence Radboud Institute for Molecular Life Sciences [Radboudumc 2]
Cellular differentiation
Cell Communication
Cell fate determination
Mechanotransduction
Cellular
Extracellular Matrix/chemistry
Article
Bone and Bones
Extracellular matrix
Tendons
03 medical and health sciences
Eukaryotic Cells/cytology
Cell Movement
Animals
Humans
Bone and Bones/cytology
Muscle
Skeletal
Process (anatomy)
Mechanotransduction
Cellular/physiology
Chemistry
Cell Movement/physiology
Brain
Cell migration
Cell Differentiation
Cell Biology
Cell biology
Extracellular Matrix
Biomechanical Phenomena
Tendons/cytology
030104 developmental biology
Eukaryotic Cells
Muscle
Skeletal/cytology
Brain/cytology
Skeletal/cytology
Organ Specificity
Cell Communication/physiology
Proteolysis
Unfolded protein response
Muscle
Cellular/physiology
Zdroj: Nature Cell Biology, 20(1), 8-20. Nature Publishing Group
Nature Cell Biology, 20, 1, pp. 8-20
Nature Cell Biology, 20, 8-20
ISSN: 1465-7392
Popis: Item does not contain fulltext Cell migration is an adaptive process that depends on and responds to physical and molecular triggers. Moving cells sense and respond to tissue mechanics and induce transient or permanent tissue modifications, including extracellular matrix stiffening, compression and deformation, protein unfolding, proteolytic remodelling and jamming transitions. Here we discuss how the bi-directional relationship of cell-tissue interactions (mechanoreciprocity) allows cells to change position and contributes to single-cell and collective movement, structural and molecular tissue organization, and cell fate decisions.
Databáze: OpenAIRE
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