Morphine may mimic the apomorphine cue by inhibiting dopaminergic autoinhibition
| Autor: | Alice M. Holohean, James B. Appel, Linda L. Hernandez |
|---|---|
| Rok vydání: | 1982 |
| Předmět: |
Male
medicine.medical_specialty Apomorphine Dopamine (+)-Naloxone Pharmacology Discrimination Learning Dextrorphan Internal medicine medicine Haloperidol Animals Levorphanol Drug Interactions Ergonovine Morphine Chemistry Rats Inbred Strains Rats Pentazocine Endocrinology Dopamine Antagonists Cues Sulpiride medicine.drug |
| Zdroj: | European Journal of Pharmacology. 78:287-294 |
| ISSN: | 0014-2999 |
| DOI: | 10.1016/0014-2999(82)90030-9 |
| Popis: | Rats were trained to discriminate the cue produced by 0.25 mg/kg apomorphine from that produced by saline, using a two-lever, drug discrimination task. This cue was blocked by haloperidol but not by DPI, ergometrine, bromocriptine, sulpiride, naloxone or naltrexone; none of these agents substituted for (mimicked) apomorphine. Morphine and levorphanol did, however, mimic apomorphine, whereas dextrorphan did not; pentazocine induced responding unlike either apomorphine or saline. The substitution of morphine for apomorphine was blocked by naltrexone or bromocriptone, and was partially antagonized by a low dose of ergometrine, but was unaffected by haloperidol or sulpiride. To explain these results, it was proposed that morphine mimics apomorphine by inhibiting dopaminergic autoregulation involving D 2 -receptors. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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