Macrophage migration inhibitory factor regulates TLR4 expression and modulates TCR/CD3-mediated activation in CD4+ T lymphocytes
| Autor: | Ekaterine Berishvili, Domenico Bosco, Véronique Serre-Beinier, Thierry Roger, Thierry Berney, Mohamed Alibashe-Ahmed, Walter Reith |
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| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
CD4-Positive T-Lymphocytes Lipopolysaccharides medicine.medical_treatment Immunology lcsh:Medicine chemical and pharmacologic phenomena ddc:616.07 Lymphocyte Activation Article Immunophenotyping Immunomodulation 03 medical and health sciences Mice 0302 clinical medicine Antigen Cell death and immune response medicine otorhinolaryngologic diseases Animals lcsh:Science Receptor Macrophage Migration-Inhibitory Factors Multidisciplinary ddc:617 Chemistry Effector Macrophages lcsh:R T-cell receptor Cell biology Intramolecular Oxidoreductases Toll-Like Receptor 4 030104 developmental biology Cytokine Gene Expression Regulation Receptor-CD3 Complex Antigen T-Cell TLR4 lcsh:Q Macrophage migration inhibitory factor Cytokine secretion 030217 neurology & neurosurgery Biomarkers |
| Zdroj: | Scientific Reports Scientific reports, vol. 9, no. 1, pp. 9380 Scientific Reports, Vol. 9, No 1 (2019) P. 9380 Scientific Reports, Vol 9, Iss 1, Pp 1-13 (2019) |
| ISSN: | 2045-2322 |
| Popis: | Toll-like receptor 4 (TLR4) is involved in CD4+ T lymphocyte-mediated pathologies. Here, we demonstrate that CD4+ T lymphocytes express functional TLR4 that contributes to their activation, proliferation and cytokine secretion. In addition, we demonstrate that TLR4-induced responses are mediated by macrophage migration inhibitory factor (MIF), a pro-inflammatory cytokine. We also demonstrate that MIF regulates suboptimal TCR/CD3-mediated activation of T lymphocytes. On one hand, MIF prevents excessive TCR/CD3-mediated activation of CD4+ T lymphocytes under suboptimal stimulation conditions and, on the other hand, MIF enables activated CD4+ T lymphocytes to sense their microenvironment and adapt their effector response through TLR4. Therefore, MIF appears to be a major regulator of the activation of CD4+ T lymphocytes and the intensity of their effector response. TLR4-mediated activation is thus an important process for T cell-mediated immunity. |
| Databáze: | OpenAIRE |
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