Electrostatically modulated magnetophoretic transport of functionalised iron-oxide nanoparticles through hydrated networks
| Autor: | Stephen Lyons, Garret Dee, Aoife Morrin, Dermot F. Brougham, Eoin P. Mc Kiernan |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
chemistry.chemical_classification
Materials science Iron oxide Magnetophoresis iron oxide hydrogel tissue mimic 02 engineering and technology Polymer 010402 general chemistry 021001 nanoscience & nanotechnology 01 natural sciences Tortuosity 0104 chemical sciences Chemistry chemistry.chemical_compound Chemical engineering chemistry Ionic strength Zeta potential Magnetic nanoparticles Agarose General Materials Science 0210 nano-technology Iron oxide nanoparticles |
| Zdroj: | Lyons, Stephen, McKiernan, Eoin P., Dee, Garret ORCID: 0000-0003-3764-6967 |
| ISSN: | 2040-3372 |
| Popis: | Factors that determine magnetophoretic transport of magnetic nanoparticles (MNPs) through hydrated polymer networks under the influence of an external magnetic field gradient were studied. Functionalised iron oxide cores (8.9 nm core diameter) were tracked in real-time as they moved through agarose gels under the influence of an inhomogeneous magnetic field. Terminal magnetophoretic velocities were observed in all cases, these were quantified and found to be highly reproducible and sensitive to the con- ditions. Increasing agarose content reduced magnetophoretic velocity, we attribute this to increasingly tortuous paths through the porous hydrated polymer network and propose a new factor to quantify the tortuosity. The impact of MNP surface functionalisation, charge, network fixed charge content, and ionic strength of the aqueous phase on velocity were studied to separate these effects. For MNPs functionalised with polyethylene glycol (PEG) increasing chain length reduced velocity but the tortuosity extracted, which is a function of the network, was unchanged; validating the approach. For charged citrate- and arginine-functionalised MNPs, magnetophoretic velocities were found to increase for particles with posi- tive and decrease for particles with negative zeta potential. In both cases these effects could be moder- ated by reducing the number of agarose anionic residues and/or increasing the ionic strength of the aqueous phase; conditions under which tortuosity again becomes the critical factor. A model for MNP transport identifying the contributions from the tortuous pore network and from electrostatic effects associated with the pore constrictions is proposed. |
| Databáze: | OpenAIRE |
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