A Randomized Trial of Objective Spectacle Prescriptions for Adults with Down Syndrome: Baseline Data and Methods
| Autor: | Kelsey R Trast, Karen D. Fern, Ayeswarya Ravikumar, Jason D Marsack, Ruth E. Manny, Heather A Anderson, Julia S. Benoit |
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| Rok vydání: | 2021 |
| Předmět: |
Adult
Male Down syndrome Visual acuity Adolescent genetic structures Population Visual Acuity Article Standard deviation law.invention Young Adult 03 medical and health sciences 0302 clinical medicine Randomized controlled trial law Surveys and Questionnaires medicine Humans Medical prescription education education.field_of_study business.industry Vision Tests Repeatability Middle Aged Refractive Errors medicine.disease eye diseases Clinical trial Ophthalmology Eyeglasses Prescriptions 030221 ophthalmology & optometry Optometry Female Down Syndrome medicine.symptom business 030217 neurology & neurosurgery |
| Zdroj: | Optom Vis Sci |
| ISSN: | 1538-9235 1040-5488 |
| DOI: | 10.1097/opx.0000000000001631 |
| Popis: | SIGNIFICANCE. It is difficult to determine the most efficacious refractive correction for individuals with Down syndrome using routine clinical techniques. New objective methods that optimize spectacle corrections for this population may reduce limitations on daily living by improving visual quality. PURPOSE. This manuscript describes the methods and baseline characteristics of study participants in a National Eye Institute sponsored clinical trial to evaluate objectively derived spectacle corrections in adults with Down syndrome. Inter-session repeatability of the primary outcome measure (distance visual acuity) is also reported. METHODS. Adults with Down syndrome were enrolled into a 9 visit study to compare clinically derived spectacle corrections and two different objective spectacle corrections derived from wavefront aberration data. Spectacle corrections were randomized and dispensed for two months each. Distance visual acuity was measured with a Bailey-Lovie style chart. Inter-session repeatability of acuity was established by performing difference versus mean analysis from binocular acuity measures obtained through habitual corrections at visits 1 and 2.b RESULTS. Thirty adults (mean ± standard deviation age = 29 ± 10 years) with a large range of refractive errors were enrolled. Presenting visual acuity at visit 1 was reduced (right eye: 0.47 ± 0.20 logMAR, left eye: 0.42 ± 0.17 logMAR). The mean difference between visits 1 and 2 was 0.02 ± 0.06 logMAR with a coefficient of repeatability (1.96 x within subject standard deviation) of 0.12 logMAR. CONCLUSIONS. This study seeks to investigate new strategies to determine optical corrections that may reduce commonly observed visual deficits in individuals with Down syndrome. The good inter-session repeatability of acuity found in this study (6 letters) indicates that, despite the presence of reduced acuity, adults with Down syndrome performed the outcome measure for this clinical trial reliably. |
| Databáze: | OpenAIRE |
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