Enzymatic Resolution of Indinavir Precursor in Ionic Liquids with Reuse of Biocatalyst and Media by Product Sublimation

Autor:	Carlos A. M. Afonso, Nuno M. T. Lourenco, Susana Barreiros
Rok vydání:	2007
Předmět:	Green chemistry Chemistry Ultra-high vacuum General Medicine Pollution Catalysis Acylation chemistry.chemical_compound Biocatalysis Ionic liquid By-product Environmental Chemistry Organic chemistry Sublimation (phase transition) Enantiomeric excess
Zdroj:	ChemInform. 38
ISSN:	1522-2667 0931-7597
DOI:	10.1002/chin.200747099
Popis:	Efficient enzymatic resolution of (±)-cis-benzyl N-(1-hydroxyindan-2-yl)carbamate in [aliq][N(CN)2] by acylation using CALB as a biocatalyst was achieved, with the possibility of catalyst and medium reuse. The reaction proceeds to the formation of the corresponding acetate in moderate yield and high enantiomeric excess for the first and second cycles. Additionally, the biocatalyst can be recovered by filtration and reaction products can be easily removed from the ionic liquid by direct sublimation under high vacuum.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::673cb0329efc77ba1c0dc3d9640a9979 https://doi.org/10.1002/chin.200747099 Zobrazit plný text záznamu Plný text