Psoriasis Severity Assessment Combining Physician and Patient Reported Outcomes: The Optimal Psoriasis Assessment Tool
| Autor: | Ying Zhang, Lotus Mallbris, Missy McKean-Matthews, Gaia Gallo, Craig L. Leonardi, Russel Burge, Kyoungah See, Orin Goldblum |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Body surface area
medicine.medical_specialty business.industry PASI OPAT Dermatology Dermatology Life Quality Index medicine.disease Placebo humanities Etanercept Correlation 030207 dermatology & venereal diseases 03 medical and health sciences Ixekizumab 0302 clinical medicine Quality of life 030220 oncology & carcinogenesis Psoriasis Internal medicine Medicine business Original Research medicine.drug |
| Zdroj: | Dermatology and Therapy |
| ISSN: | 2190-9172 2193-8210 |
| DOI: | 10.1007/s13555-021-00544-6 |
| Popis: | Introduction Psoriasis Area Severity Index (PASI) assessment is complex and time-consuming. A simpler assessment measure more sensitive to changes in symptom severity and predictive of patients’ quality of life (Dermatology Life Quality Index, DLQI) is needed. This study aims to evaluate the Optimal Psoriasis Assessment Tool (OPAT) as an alternative to PASI. Methods This integrated analysis of three UNCOVER trials (NCT01474512, NCT01597245, and NCT01646177) randomized patients (N = 3866) with moderate-to-severe psoriasis to subcutaneously administered ixekizumab 80 mg Q2W or Q4W, or placebo or etanercept 50 mg Q2W. Pearson correlations were computed for clinical and patient-reported measures with PASI and DLQI. Results As the correlations with PASI and BSA were high and not much higher when adding severity, body surface area (BSA) was used for the clinical measure. BSA was the main measure influencing OPAT. Week 12 regression analyses results showed that PASI had a higher correlation with BSA combined with patient assessments than with BSA alone. Sensitivity analyses were also completed for PASI 75 and 90. For DLQI, correlations with the combined measures were even stronger than with BSA alone. A comprehensive model selection procedure was conducted, which illustrated that the two-term models are preferred. Conclusion The OPAT is a simple and time-saving alternative to PASI. It can be derived using BSA and patient-reported assessments having strong correlation with PASI and moderate correlation with DLQI. Supplementary Information The online version contains supplementary material available at 10.1007/s13555-021-00544-6. |
| Databáze: | OpenAIRE |
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