Large-Scale 3–5 Hz Oscillation Constrains the Expression of Neocortical Fast Ripples in a Mouse Model of Mesial Temporal Lobe Epilepsy

Autor: Gwénaël Birot, Charles Quairiaux, Christoph M. Michel, Laurent Sheybani, Pieter van Mierlo
Rok vydání: 2019
Předmět:
Male
Action Potentials
LOBECTOMY
Neocortex
cross-frequency coupling
Hippocampal formation
Electroencephalography
Inbred C57BL
Mice
Epilepsy
0302 clinical medicine
Medicine and Health Sciences
Premovement neuronal activity
EEG
BRAIN
Neurons
Physics
0303 health sciences
medicine.diagnostic_test
General Neuroscience
General Medicine
oscillation
NETWORKS
fast-ripples
medicine.anatomical_structure
3.6
Temporal Lobe/physiopathology
Neocortex/physiopathology
NEURONAL FIRING PATTERNS
Sensory system
Brain Waves/physiology
Animals
Disease Models
Animal
Epilepsy
Temporal Lobe/physiopathology
Mice
Inbred C57BL
Neurons/physiology
epilepsy
epileptic network
03 medical and health sciences
medicine
Ictal
030304 developmental biology
HIPPOCAMPAL
Confirmation
Animal
Biology and Life Sciences
EPILEPTIFORM DISCHARGES
GAMMA
medicine.disease
Brain Waves
ddc:616.8
Coupling (electronics)
Epilepsy
Temporal Lobe
FOCAL EPILEPSY
Disease Models
Disorders of the Nervous System
SEIZURE ONSET
Neuroscience
030217 neurology & neurosurgery
Zdroj: eNeuro
ENEURO
eNeuro, vol. 6, no. 1
eNeuro, Vol. 6, No 1 (2019) pp. 1-13
ISSN: 2373-2822
DOI: 10.1523/eneuro.0494-18.2019
Popis: Large-scale slow oscillations allow the integration of neuronal activity across brain regions during sensory or cognitive processing. However, evidence that this form of coding also holds for pathological networks, such as for distributed networks in epileptic disorders, does not yet exist. Here, we show in a mouse model of unilateral hippocampal epilepsy that epileptic fast ripples generated in the neocortex distant from the primary focus occur during transient trains of interictal epileptic discharges. During these epileptic paroxysms, local phase-locking of neuronal firing and a phase–amplitude coupling of the epileptic discharges over a slow oscillation at 3–5 Hz are detected. Furthermore, the buildup of the slow oscillation begins in the bihippocampal network that includes the focus, which synchronizes and drives the activity across the large-scale epileptic network into the frontal cortex. This study provides the first functional description of the emergence of neocortical fast ripples in hippocampal epilepsy and shows that cross-frequency coupling might be a fundamental mechanism underlying the spreading of epileptic activity.
Databáze: OpenAIRE
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