Comparison of the clinical efficacy of preserved and preservative-free hydroxypropyl methylcellulose-dextran-containing eyedrops
| Autor: | Pedram Akbarshahi, Parvin Azizzadeh, Masoud Safarzadeh |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Male
0301 basic medicine Preservative medicine.medical_treatment Artificial tear drops Administration Ophthalmic Cornea chemistry.chemical_compound Benzalkonium chloride Hypromellose Derivatives 0302 clinical medicine lcsh:Ophthalmology Surveys and Questionnaires lcsh:QC350-467 Single-Blind Method Ocular Surface Disease Index Clinical efficacy Hydroxypropyl methylcellulose Dextrans Middle Aged Drug Combinations Artificial tears Treatment Outcome Dextran Original Article Dry Eye Syndromes Female Benzalkonium Compounds lcsh:Optics. Light medicine.drug Adult Lágrimas artificiales medicine.medical_specialty Hidroxipropil metilcelulosa Lubricant Eye Drops 03 medical and health sciences Ophthalmology medicine Humans Dry eye syndrome business.industry Preservatives Pharmaceutical Eyelids Repeated measures design Síndrome de ojo seco Dextran 70 030104 developmental biology chemistry lcsh:RE1-994 Tears 030221 ophthalmology & optometry Ophthalmic Solutions business Optometry |
| Zdroj: | Journal of Optometry Journal of Optometry, Vol 10, Iss 4, Pp 258-264 (2017) |
| ISSN: | 1888-4296 |
| DOI: | 10.1016/j.optom.2016.11.002 |
| Popis: | Purpose: This study aimed to compare the efficacy of two sustained-release formulation of artificial tear drops. Patients and methods: This is a randomized patient-masked clinical trial, a total 88 patients into two group A (n = 41; with single dose of artificial tear, containing dextran 70, 1 mg/ml and hypromellose, 3 mg/ml hydroxypropyl methylcellulose (HPMC) and group B (n = 47; with multidose of artificial tear, containing 0.3 g HPMC and 0.1 g of dextran 70, with 0.01% benzalkonium chloride (BAK) as preservative) were completed the study. The ocular surface disease index (OSDI) questionnaire, tear break up time (TBUT), corneal and conjunctival staining and Schirmer test, were performed. Repeated measures ANOVA was used to assess the differences among the two products. A p-value less than 0.05 was considered significant. Results: The mean of age of the participants in the Group A and B was 44.08 ± 6.29 (range, 33–58 years) years and 45.83 ± 8.42 (31–60 years), respectively. In comparing two groups before the intervention, the OSDI scores, the TBUT scores, the conjunctival and corneal staining scores and the Schirmer scores did not show statistically significant differences (p = 0.339, p = 0.640, p = 0.334, p = 0.807 and p = 0.676, respectively). After 4 weeks, the OSDI scores, conjunctival and corneal staining scores showed improvement in compare to those before the intervention (p |
| Databáze: | OpenAIRE |
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