Increased aqueous humor basic fibroblast growth factor and hyaluronan levels in relation to the exfoliation syndrome and exfoliative glaucoma
| Autor: | Fotini N. Lamari, Ephigenia K. Mela, A. Exarchou, Sotirios P. Gartaganis, Constantine D. Georgakopoulos, Nikos K. Karamanos |
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| Rok vydání: | 2001 |
| Předmět: |
Male
medicine.medical_specialty Pathology Basic fibroblast growth factor Connective tissue Glaucoma Aqueous humor Cataract Extraction Exfoliation Syndrome Exfoliative glaucoma Exfoliation syndrome Aqueous Humor Immunoenzyme Techniques Pathogenesis chemistry.chemical_compound Ophthalmology Hyaluronic acid Humans Medicine Hyaluronic Acid Chromatography High Pressure Liquid Aged Aged 80 and over business.industry Middle Aged medicine.disease eye diseases medicine.anatomical_structure chemistry Female Fibroblast Growth Factor 2 sense organs business |
| Zdroj: | Acta Ophthalmologica Scandinavica. 79:572-575 |
| ISSN: | 1395-3907 |
| DOI: | 10.1034/j.1600-0420.2001.790605.x |
| Popis: | Purpose: To quantify the concentrations of basic fibroblast growth factor (bFGF) and hyaluronan (HA) in the aqueous humor of patients with the exfoliation syndrome (XFS) or exfoliative glaucoma (XFG). Methods: Aqueous humor bFGF and HA levels were measured in 13 patients with XFS and in 7 patients with XFG. The results were compared with those obtained from 17 healthy controls. Results: Mean bFGF levels were significantly higher in the XFG patients than those in the XFS patients, which in turn were higher than the bFGF levels in the healthy individuals. Aqueous humor HA levels in both patients with the XFS and the XFG were significantly higher compared to the controls. Conclusion: We suggest that bFGF plays an important role in the pathogenesis of XFS and XFG, as well as in the synthesis of secreted HA, which may result in connective tissue degradation that affects the ocular anterior segment. |
| Databáze: | OpenAIRE |
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