Can an early weight management program (WMP) prevent olanzapine (OLZ)-induced disturbances in body weight, blood glucose and lipid metabolism? Twenty-four- and 48-week results from a 6-month randomized trial
| Autor: | Joachim Cordes, Johanna Thünker, Christoph U. Correll, Hans Hauner, Marcus W. Agelink, Gunnar Regenbrecht, Christian Schmidt-Kraepelin, Christian Lange-Asschenfeldt, Kai G. Kahl, Wolfgang Gaebel, Ansgar Klimke, Jürgen Zielasek |
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| Rok vydání: | 2011 |
| Předmět: |
Adult
Blood Glucose Male Olanzapine medicine.medical_specialty Schizoaffective disorder Body Mass Index law.invention Benzodiazepines Randomized controlled trial law Early Medical Intervention Internal medicine Diabetes mellitus Glucose Intolerance Weight management medicine Humans Obesity Biological Psychiatry Dyslipidemias business.industry Middle Aged Anthropometry medicine.disease Weight Reduction Programs Psychiatry and Mental health Endocrinology Diabetes Mellitus Type 2 Psychotic Disorders Schizophrenia Female medicine.symptom business Weight gain Body mass index Antipsychotic Agents medicine.drug |
| Zdroj: | The World Journal of Biological Psychiatry. 15:229-241 |
| ISSN: | 1814-1412 1562-2975 |
| DOI: | 10.3109/15622975.2011.592546 |
| Popis: | This study was designed to investigate whether a preventive weight management program (WMP) reduces weight gain during olanzapine (OLZ) treatment. Moreover, we examined the effects of intervention on metabolic parameters.Patients (N = 100) with schizophrenia or schizoaffective disorder (DSM-IV) who had commenced treatment with OLZ were recruited. Following a run-in period of 4 weeks, 74 patients who had gained at least 1.5 kg body weight were randomized to receive either 12 bi-weekly WMP sessions (prevention group (PG), n = 36), or usual care (control group (CG), n = 38). Anthropometric and metabolic parameters were assessed after the 24-week intervention phase and a 24-week follow-up.Forty-two percent of 74 participants (PG: 36.1%, CG: 47.4%) finished the 24-week intervention phase while 34% of them (PG: 30.6%, CG: 36.8%) completed the 48-week study. There was no significant difference in weight gain between groups (PG: + 3.4 ± 4.2 kg vs. CG: + 4.5 ± 6.1 kg, P = 0.184) after 24 weeks. Nevertheless, PG showed a significantly smaller increase in waist circumference than CG (PG: + 4.6 ± 8.3 cm, CG: + 10.1 ± 7.3 cm, P = 0.019) after 48 weeks. Furthermore, PG showed a significantly smaller increase in fasting glucose (P = 0.031) and 2-h glucose after oral glucose load (P = 0.018) than CG.These results suggest that preventive WMP may reduce the risk of abdominal obesity and deterioration of glucose metabolism in OLZ-treated patients. |
| Databáze: | OpenAIRE |
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