Chemical studies on the roots of Uvaria welwitschii
| Autor: | Noriyoshi Nakatani, Momoyo Ichimaru, Masataka Moriyasu, Francis D. Juma, Yumi Nishiyama, Simon G. Mathenge, Atsushi Kato, Patrick B. Chalo Mutiso |
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| Rok vydání: | 2011 |
| Předmět: |
Magnetic Resonance Spectroscopy
Cell Survival Stereochemistry Flavonoid Annonaceae Antineoplastic Agents HL-60 Cells Uvaria welwitschii Biology Plant Roots chemistry.chemical_compound Stomach ache Humans Organic chemistry Moiety Cytotoxicity Chromatography High Pressure Liquid Flavonoids chemistry.chemical_classification Chloroform Molecular Structure biology.organism_classification chemistry Molecular Medicine African traditional medicine |
| Zdroj: | Journal of Natural Medicines. 65:313-321 |
| ISSN: | 1861-0293 1340-3443 |
| Popis: | A chemical investigation of the chloroform extract of the roots of Uvaria welwitschii (Annonaceae), an African traditional medicine taken for stomach ache, led to the isolation of eight new compounds, named welwitschins A-H (1-8), together with five known compounds (9-13). The structural elucidation by spectroscopic studies of the compounds isolated is described. All new compounds were flavonoids having a 2-hydroxy-3,4,6-trimethoxyphenyl moiety in the A-ring, and unsubstituted phenyl in the B-ring. Four of them (1-4) were monomeric flavonoids while the others (5-8) were dimeric flavonoids. The cytotoxicity of the isolated compounds against human promyelocytic leukemia HL-60 cells was investigated. |
| Databáze: | OpenAIRE |
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