Chemical constituents and antibacterial activity from the stems and leaves of Piper wallichii
| Autor: | Jakkapat Paluka, Chalermpol Suwanphakdee, Somdej Kanokmedhakul, Kwanjai Kanokmedhakul, Trinop Promgool, Chalini Nongmai |
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| Rok vydání: | 2021 |
| Předmět: |
Pharmacology
biology 010405 organic chemistry Stereochemistry Organic Chemistry Bacillus cereus Pharmaceutical Science General Medicine Piperaceae Carbon-13 NMR biology.organism_classification 01 natural sciences Piperlonguminine 0104 chemical sciences Analytical Chemistry 010404 medicinal & biomolecular chemistry chemistry.chemical_compound Complementary and alternative medicine chemistry Phytochemical Piperine Drug Discovery Molecular Medicine Piperidine Antibacterial activity |
| Zdroj: | Journal of Asian Natural Products Research. 24:344-352 |
| ISSN: | 1477-2213 1028-6020 |
| Popis: | A phytochemical investigation of the stems and leaves of Piper wallichii led to the isolation of two new compounds, an aryl alkanone, piwalkanone (1) and a dioxoaporphine alkaloid, piwallidione (2), together with nine known compounds, a dioxoaporphine alkaloid, cepharadione A (3); two aristolactams, piperolactam A (4) and stigmalactam (5); a piperidine, piperine (6); four isobutylamides, piperlonguminine (7), pellitorine (8), N���isobutyl���2E,4E���octadecadienamide (9), and guineensine (10); and a tyramine, N-trans-feruloyltyramine (11). Their structures were elucidated on the basis of spectroscopic evidence (IR, 1H NMR, 13C NMR and 2 D NMR) and MS. Compounds 2 and 3 showed inhibitory activities against pathogenic bacteria, Bacillus cereus, Bacillus subtilis and Staphylococcus aureus. |
| Databáze: | OpenAIRE |
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