Objective evaluation and predictive value of olfactory dysfunction among patients hospitalized with COVID-19
Autor: | Thiago Sasso Carmona de Souza, Rogério Hamerschmidt, Patrícia Cristina Scarabotto, Roberta David João De Masi, Marcelly Botelho Soares, Lucas Resende Lucinda Mangia |
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Rok vydání: | 2021 |
Předmět: |
Adult
Male Olfactory system medicine.medical_specialty ARDS Coronavirus disease 2019 (COVID-19) Anosmia Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Severity of Illness Index law.invention Olfaction Disorders 03 medical and health sciences 0302 clinical medicine law Internal medicine Statistical significance Intubation Intratracheal medicine Humans Hospital Mortality Longitudinal Studies Prospective Studies 030223 otorhinolaryngology Aged Respiratory Distress Syndrome SARS-CoV-2 business.industry Smell disorders COVID-19 General Medicine Length of Stay Middle Aged Prognosis medicine.disease Predictive value Intensive care unit Patient Discharge Hospitalization Intensive Care Units Severe acute respiratory syndrome Otorhinolaryngology Case-Control Studies 030220 oncology & carcinogenesis Female Original Article Surgery medicine.symptom business |
Zdroj: | Auris Nasus Larynx Auris, Nasus, Larynx |
ISSN: | 0385-8146 |
Popis: | Objectives Olfactory dysfunction is a frequent feature of COVID-19. Despite the growing evidence, current knowledge on the subject remains insufficient, so that data obtained with different tools, from multiple centers and in distinct scenarios are welcome. Yet, the predictive value of olfactory dysfunction in terms of the overall prognosis of COVID-19 is unknown. This study aims to evaluate the olfactory function of hospitalized patients with COVID-19 and the impact of the results on their clinical outcomes. Methods Patients with severe acute respiratory distress syndrome (ARDS) admitted to a university tertiary hospital were recruited and divided into those with ARDS due to COVID-19, and those with ARDS of any other cause. Sociodemographic and clinical data were collected at baseline and the patients had their objective olfactory function evaluated by the Alcohol Sniff Test on admission and during hospital stay. The participants were then followed up until reaching an endpoint: hospital discharge, endotracheal intubation, transfer to the intensive care unit, or death. Patients with COVID-19 were also subgrouped and compared according to their olfactory thresholds and to their overall clinical outcomes. The obtained data was analyzed using R software. Level of significance was set at 0.05. Results Eighty-two patients were included (of which 58 had COVID-19). 87.93% of the patients with COVID-19 had diminished olfactory dysfunction on admission. The mean length of hospital stay among patients with olfactory dysfunction was greater (7.84 vs 6.14 days) and nine individuals in this subgroup had poor overall outcomes. None of those with normal olfactory function developed critical COVID-19. The mean olfactory function was significantly worse among patients with COVID-19 and poor outcomes (3.97 vs 7.90 cm, P = .023). Conclusion Objective olfactory dysfunction is frequent in ARDS caused by SARS-CoV-2 infection. Patients with longitudinal poorer outcomes present worse olfactory thresholds on admission. |
Databáze: | OpenAIRE |
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