Ultradian feeding in mice not only affects the peripheral clock in the liver, but also the master clock in the brain
| Autor: | Stéphanie Dumont, Satish Sen, Etienne Challet, Andries Kalsbeek, Helene Raingard, Patrick Vuillez |
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| Přispěvatelé: | Institut des Neurosciences Cellulaires et Intégratives (INCI), Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS), Netherlands Institute for Neuroscience (NIN), AGEM - Amsterdam Gastroenterology Endocrinology Metabolism, ANS - Cellular & Molecular Mechanisms, Endocrinology, Endocrinology Laboratory |
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty endocrine system Physiology [SDV]Life Sciences [q-bio] Period (gene) CLOCK Proteins Biology Eating Mice 03 medical and health sciences Biological Clocks Physiology (medical) Internal medicine medicine Animals Circadian rhythm Animal Husbandry ComputingMilieux_MISCELLANEOUS Ultradian rhythm 2. Zero hunger Suprachiasmatic nucleus Body Weight Brain Animal Feed Circadian Rhythm PER2 CLOCK 030104 developmental biology Endocrinology Gene Expression Regulation Liver Suprachiasmatic Nucleus [SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC] sense organs Energy Intake Food Deprivation PER1 |
| Zdroj: | Chronobiology International Chronobiology International, Taylor & Francis, 2017, 34 (1), pp.17-36. ⟨10.1080/07420528.2016.1231689⟩ Annual Review of Chronopharmacology, 34, 17-36. Marcel Dekker Chronobiology international, 34(1), 17-36. Marcel Dekker Inc. |
| ISSN: | 0743-9539 0742-0528 1525-6073 |
| DOI: | 10.1080/07420528.2016.1231689⟩ |
| Popis: | Restricted feeding during the resting period causes pronounced shifts in a number of peripheral clocks, but not the central clock in the suprachiasmatic nucleus (SCN). By contrast, daily caloric restriction impacts also the light-entrained SCN clock, as indicated by shifted oscillations of clock (PER1) and clock-controlled (vasopressin) proteins. To determine if these SCN changes are due to the metabolic or timing cues of the restricted feeding, mice were challenged with an ultradian 6-meals schedule (1 food access every 4 h) to abolish the daily periodicity of feeding. Mice fed with ultradian feeding that lost 10% body mass (i.e. hypocaloric) became more diurnal, hypothermic in late night, and displayed larger (3.5 h) advance of body temperature rhythm, more reduced PER1 expression in the SCN, and further modified gene expression in the liver (e.g. larger phase-advance of Per2 and up-regulated levels of Pgc-1α). While glucose rhythmicity was lost under ultradian feeding, the phase of daily rhythms in liver glycogen and plasma corticosterone (albeit increased in amplitude) remained unchanged. In conclusion, the additional impact of hypocaloric conditions on the SCN are mainly due to the metabolic and not the timing effects of restricted daytime feeding. |
| Databáze: | OpenAIRE |
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