Combined Stereotactic Body Radiotherapy and Immunotherapy Versus Transarterial Chemoembolization in Locally Advanced Hepatocellular Carcinoma: A Propensity Score Matching Analysis

Autor:	Chi-Leung Chiang, Keith Wan-Hang Chiu, Francis Ann-Shing Lee, Feng-Ming Spring Kong, Albert Chi-Yan Chan
Rok vydání:	2021
Předmět:	liver cancer immune checkpoint inhibitors Cancer Research Oncology stereotactic body radiotherapy Neoplasms. Tumors. Oncology. Including cancer and carcinogens transarterial chemoembolization immunotherapy hepatocellular carcinoma radiotherapy RC254-282 Original Research
Zdroj:	Frontiers in Oncology, Vol 11 (2021) Frontiers in Oncology
ISSN:	2234-943X
Popis:	Immunotherapy has achieved modest clinical activity in HCC patients. Propensity score matching analysis was conducted to compare the efficacy and safety of combined stereotactic SBRT-IO versus TACE in patients with locally advanced HCC in a tertiary centre of Hong KongPatients with locally advanced HCC who were medically inoperable for, refractory to, or refused to curative surgical interventions were eligible. The primary outcome was PFS; the secondary outcomes were OS, ORR as per mRECIST version 1.1, and TRAEs. Matching pair analysis was performed to compare the clinical outcomes.A total of 226 patients were eligible. 16 patients in the SBRT-IO group were matched with 48 patients treated with TACE. The median tumour size was 10 cm (range: 2.9-19.6 cm) and 20.3% of the patients had portal vein invasion. The 12-month and 24-month PFS were significantly better in the SBRT-IO group (93.3% vs 16.7% and 77.8% vs 2.1%, respectively, p
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67365ca7acfa785454e447ac760f9988 https://pubmed.ncbi.nlm.nih.gov/34950594 Zobrazit plný text záznamu