Neutrophils: As a Key Bridge between Inflammation and Thrombosis

Autor: Pengxiang Xu, Liuyan Xin, Xiaoping Xiao, Yong Huang, Chuanming Lin, Xiaofang Liu, Haiyan Wei, Rong Xu, Yijian Chen
Rok vydání: 2022
Předmět:
Zdroj: Evidence-Based Complementary and Alternative Medicine. 2022:1-7
ISSN: 1741-4288
1741-427X
DOI: 10.1155/2022/1151910
Popis: Immunothrombosis is a mechanism of defense of the organism against pathogenic microorganisms that increases their recognition, limitation, and clearance and is part of the innate immune defense. Physiological immunothrombosis is beneficial to the body against the invasion of pathogenic microorganisms, but when immunothrombosis is out of control, it is easy to cause thrombotic diseases, thus, causing unpredictable consequences to the body. Neutrophils play a pivotal role in this process. Understanding the mechanism of neutrophils in immune thrombosis and out-of-control is particularly important for the treatment of related thrombotic diseases. In this review, we studied the role of neutrophils in immune thrombosis and each link out of control (including endothelial cell dysfunction; activation of platelets; activation of coagulation factor; inhibition of the anticoagulation system; and inhibition of the fibrinolysis system).
Databáze: OpenAIRE
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