Polyethylene glycol-conjugated immunoliposomes specific for olfactory ensheathing glial cells
| Autor: | E. A. Tsibulkina, Vladimir P. Chekhonin, Olga I. Gurina, A. E. Ryabinina, Yu. A. Zhirkov, O. V. Ykhova |
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| Rok vydání: | 2008 |
| Předmět: |
Olfactory Nerve
Drug Evaluation Preclinical Nerve Tissue Proteins Biology General Biochemistry Genetics and Molecular Biology Polyethylene Glycols Olfactory mucosa Mice Olfactory nerve Olfactory Mucosa Antibody Specificity Immunoliposome Glial Fibrillary Acidic Protein medicine Animals Cells Cultured Myelin Sheath Olfactory Epithelial Cell Mice Inbred BALB C Glial fibrillary acidic protein Antibodies Monoclonal General Medicine GFAP stain Molecular biology Cell biology Rats medicine.anatomical_structure Organ Specificity Liposomes biology.protein Female Olfactory ensheathing glia Olfactory epithelium Neuroglia |
| Zdroj: | Bulletin of experimental biology and medicine. 145(4) |
| ISSN: | 0007-4888 |
| Popis: | A novel immunoliposome delivery system was developed for directed transport into cultured olfactory epithelium cells. Monoclonal antibodies against glial fibrillary acidic protein (GFAP) served as a vector. Fluorescence microscopy showed that the target cells are specifically stained with Dil dye incorporated into liposomal membranes. This transport system holds promise for the delivery of bioactive substances to olfactory epithelial cells and modulation of their capacity to stimulate axonal regeneration. |
| Databáze: | OpenAIRE |
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