| Autor: |
Rosalie C. Sears, Goutham Narla, Michael Ohlmeyer, Dale J. Christensen, Brett Sheppard, Charles D. Lopez, Owen J. Sansom, Jennifer P. Morton, Katherine R. Pelz, Mary C. Thoma, Zina P. Jenny, Zhiping Wang, Zipei Feng, Tyler Risom, Brittany L. Allen-Petersen |
| Rok vydání: |
2023 |
| Popis: |
Supplemental Figures S1-S9. S1: Kinase inhibitor screen and response of OP449 and INK128. S2: CI values for DT1154 combined with INK128 and viability curves. S3: Kmeans clusters and signaling in response to PP2A activators and INK128. S4: Oncoprint and survival curves of patients with alterations in the MYC/mTOR pathway. S5: pT58 MYC expression levels in PDA cells treated with DT1154 and INK128. S6: Signaling with B56a knockdown or T58A MYC overexpression in response to DT1154 and INK128 treatment. S7: Signaling showing decreased expression of MYC increases the efficacy of INK128. S8: Treatment of KPC and KPCM/+ cell lines with BEZ235, Dasatinib, and Sunitinib. S9: Endpoint analysis of long- and short-term in vivo treatment with DT1154 and INK128. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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