Role of Circulating Leukocytes in the Production of Virus-Inhibiting Factor or Interferon
| Autor: | Yasuiti Nagano, Wataru Nakamura, Nobutoshi Maehara |
|---|---|
| Rok vydání: | 1970 |
| Předmět: |
Newcastle disease virus
medicine.disease_cause Antiviral Agents Newcastle disease Virus Andrology Leukocyte Count Mice Interferon Escherichia coli Leukocytes medicine Animals Stomatitis Normal range biology General Medicine biology.organism_classification medicine.disease Endotoxins Radiation Effects Titer Injections Intravenous Immunology Interferons Blood stream medicine.drug |
| Zdroj: | Japanese Journal of Microbiology. 14:209-213 |
| ISSN: | 0021-5139 |
| DOI: | 10.1111/j.1348-0421.1970.tb00511.x |
| Popis: | The relationship between the number of circulating leukocytes and amount of virus-inhibiting factor (IF) or interferon appearing in blood stream in response to injection of E. coli endotoxin or Newcastle disease virus (NDV) was studied in mice after whole-body X-irradiation. Two days after irradiation with 500 R, the leukocyte count fell to 7% of the normal value. Production of IF, however, was not depressed when induced with endotoxin 2 days after irradiation, while NDV induced a slightly lower titer of IF, 1/1.6 of that in non-irradiated mice. When induced 5 days after irradiation, though leukocyte count remained at 8 to 9% of the normal value, IF titers attained were only 1/3 and 1/4 of the control value with endotoxin and NDV, respectively. In mice given 1000 R before 2 days, leukocyte number was less than 1% of the normal value, while IF titers reached 1/2.7 and 1/5 of that in the control mice with endotoxin and NDV, respectively. The lack of parallel between the leukocyte count and amount of IF produced suggest that circulating leukocytes do not produce IF. |
| Databáze: | OpenAIRE |
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