Overexpression of chloride channel-3 (ClC-3) is associated with human cervical carcinoma development and prognosis
Autor: | Yutao Guan, Yang-ping Chen, Gang Wang, Yong Xie, Hai-yan Shi, Li-jiang Xu, Xiao-lu Zhang, Yi Luan, Xi-ming Shen, Hui Zhou, Zhong-qiu Lin, Yu-yuan Zhu |
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Jazyk: | angličtina |
Rok vydání: | 2019 |
Předmět: |
Cancer Research
Pathology medicine.medical_specialty Development lcsh:RC254-282 Metastasis 03 medical and health sciences 0302 clinical medicine Genetics Carcinoma medicine Neoplasm Clinical significance lcsh:QH573-671 Lymph node Cervical carcinoma Cervical cancer business.industry urogenital system lcsh:Cytology HPV infection medicine.disease Prognosis lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens medicine.anatomical_structure Oncology 030220 oncology & carcinogenesis Chloride channel-3 (ClC-3) Immunohistochemistry business Primary Research |
Zdroj: | Cancer Cell International, Vol 19, Iss 1, Pp 1-11 (2019) Cancer Cell International |
ISSN: | 1475-2867 |
Popis: | Background Cervical carcinoma is a major gynecological cancer and causes cancer-related deaths in worldwide, the latent pathogenesis and progress of cervical cancer is still under research. ClC-3 may be an important promoter for aggressive metastasis of malignant tumors. In this research, we explore the ClC-3 expression in cervical carcinoma and its underlying clinical significance, trying to illuminate ClC-3 probable function in the neoplasm malignant behavior, development and prognosis. Methods Paraffin-embedded cervical (n = 168) and lymph node (n = 100) tissue specimens were analysed by immunohistochemistry. Fresh human cervical tissue specimens (n = 165) and four human cervical cell lines were tested for ClC-3 mRNA and protein expression levels by quantitative real-time PCR and western blotting. The relationship between the expression levels of ClC-3, the pathological characteristics of the carcinoma, and the clinical prognosis were statistically analysed. Results In normal and precancerous (LSIL, HSIL) cervical tissues as well as cervical carcinoma tissues, both ClC-3 mRNA and protein expression levels increased significantly (p |
Databáze: | OpenAIRE |
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