Stroke risk among patients with chronic obstructive pulmonary disease: A systematic review and meta-analysis
| Autor: | Sewan Kim, Dong Kyun Park, Yong Joo Lee, In Cheol Hwang, Eun Bee Ham, Yu Ree Kim |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
Risk
medicine.medical_specialty Chronic Obstructive Pulmonary Disease Review Article Cochrane Library Risk Assessment Pulmonary Disease Chronic Obstructive 03 medical and health sciences 0302 clinical medicine Internal medicine Confidence Intervals medicine Humans 030212 general & internal medicine Prospective cohort study Life Style Stroke lcsh:R5-920 business.industry Hazard ratio General Medicine Publication bias medicine.disease Observational Studies as Topic Socioeconomic Factors 030228 respiratory system Meta-analysis Cerebrovascular Disease Observational study business Risk assessment lcsh:Medicine (General) Meta-Analysis |
| Zdroj: | Clinics, Volume: 73, Article number: e177, Published: 03 MAY 2018 Clinics, Vol 73, Iss 0 (2018) Clinics; v. 73 (2018); e177 Clinics; Vol. 73 (2018); e177 Clinics Universidade de São Paulo (USP) instacron:USP |
| ISSN: | 1980-5322 1807-5932 |
| Popis: | Increased stroke risk among chronic obstructive pulmonary disease patients has not yet been established. In this study, we conducted a systematic review and meta-analysis to assess stroke risk among chronic obstructive pulmonary disease patients. PubMed, EMBASE, and the Cochrane Library were systematically searched from database inception until December 31, 2016 to identify longitudinal observational studies that investigated the association between chronic obstructive pulmonary disease and stroke. Stroke risk was quantified by overall and subgroup analyses, and a pooled hazard ratio was calculated. Study quality was evaluated using the Newcastle-Ottawa Scale. Publication bias was assessed using Begg's rank correlation test. Eight studies met the inclusion criteria. In a random-effects model, significantly increased stroke risk was observed among chronic obstructive pulmonary disease patients (hazard ratio, 1.30; 95% confidence interval, 1.18-1.43). In subgroup analyses stratified by stroke subtype, study quality, and adjustment by socioeconomic status, the association between increased stroke risk and chronic obstructive pulmonary disease patients was robust. Statistically significant publication bias was not detected. In summary, chronic obstructive pulmonary disease was found to be associated with increased stroke risk. Additional prospective studies are required to elucidate the mechanisms underlying the increase in stroke risk and identify effective preventive interventions. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|