Cirrhosis complicating Shwachman-Diamond syndrome: A case report
| Autor: | Lucille McLoughlin, Michael J. Nowicki, Sandra M Camacho |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Shwachman–Diamond syndrome
medicine.medical_specialty Cirrhosis medicine.diagnostic_test Shwachman-Diamond syndrome business.industry Hepatosplenomegaly Liver dysfunction General Medicine medicine.disease Gastroenterology Internal medicine Liver biopsy Case report Failure to thrive Etiology Medicine Elevated transaminases medicine.symptom business Exocrine pancreatic insufficiency |
| Zdroj: | World Journal of Clinical Cases |
| ISSN: | 2307-8960 |
| Popis: | Background The features of Shwachman-Diamond syndrome (SDS) include exocrine pancreatic insufficiency, skeletal abnormalities and bone marrow dysfunction; an often overlooked feature is hepatic involvement. Case summary We report a child who initially presented with failure to thrive and mildly elevated transaminase levels and was determined to have pancreatic insufficiency due to SDS. During follow-up he had persistently elevated transaminase levels and developed hepatosplenomegaly. An investigation was performed to determine the etiology of ongoing liver injury, including a liver biopsy which revealed hepatic cirrhosis. Conclusion Cirrhosis has rarely been reported with SDS. While many of the hepatic disorders associated with SDS improve with age, there are rare exceptions with serious implications for long-term outcome. |
| Databáze: | OpenAIRE |
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