Homeostatic changes of some trace elements in geriatric rats in the condition of oxidative stress induced by aluminum and the beneficial role of resveratrol
| Autor: | Florin Muselin, Romeo Teodor Cristina, Ioan Bănățean-Dunea, Alexandru O. Doma, Eugenia Dumitrescu, Zeno Gârban, Alexandru B. Vițălaru |
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| Rok vydání: | 2019 |
| Předmět: |
Male
medicine.medical_specialty medicine.medical_treatment 010501 environmental sciences Resveratrol medicine.disease_cause 01 natural sciences Biochemistry Inorganic Chemistry Superoxide dismutase 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Internal medicine medicine Animals Homeostasis Rats Wistar Saline 0105 earth and related environmental sciences biology Albumin Glutathione Rats Trace Elements Oxidative Stress Endocrinology chemistry Catalase biology.protein Molecular Medicine Alum Compounds Female Hemoglobin 030217 neurology & neurosurgery Oxidative stress Injections Intraperitoneal |
| Zdroj: | Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS). 55 |
| ISSN: | 1878-3252 |
| Popis: | Background Elderly individuals are exposed to trace element imbalances due to the reduced capacity of their organism to utilize minerals in a direct relationship with many circumstances. Objectives and methods The aim of this study was to assess the protective role of resveratrol upon the homeostatic changes of some trace elements in geriatric rats in the condition of oxidative stress induced by aluminum exposure. Forty Wistar rats, 18–20 months old, were divided randomly into four groups (n = 10): control (C) - receiving 1 ml of physiologically saline (P.S.) via intraperitoneal (i.p) administration, E1 - 1 ml of P.S. and 1000 ppb aluminum sulphate (AS) in drinking water ad libitum, E2 - 20 mg/kg−1 resveratrol, i.p. and 1000 ppb AS in drinking water, E3 - 20 mg/kg−1 resveratrol i.p. The groups C and E3 received distilled water as drinking water ad libitum. The i.p administrations were once a week for four weeks period. The levels of oxidative stress marker's were analyzed (glutathione, glutathione' peroxidase, superoxide dismutase, and catalase) of the proteins' (total protein, albumin, and hemoglobin) in serum and also the levels of the main trace elements (copper, zinc, iron, selenium, manganese and magnesium) in blood, liver, kidney and spleen. Results Significant decrease (p 0.05) increase of Se and Mn in blood, significant (p 0.05) were recorded in groups which received resveratrol (E2 and E3) compared to the control group, but significant differences (p Conclusions The results suggest that resveratrol can prevent the homeostatic imbalance of trace elements in geriatric rats in the condition of oxidative stress induced by aluminum exposure. |
| Databáze: | OpenAIRE |
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