Cross-Sectional Analysis of Quality of Life in Pediatric Patients with Inflammatory Bowel Disease in British Columbia, Canada
| Autor: | Alam Lakhani, Carlie Penner, Theresa Newlove, Kevan Jacobson, Matthew Smyth, Kathi Evans, Justin M. Chan |
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| Rok vydání: | 2021 |
| Předmět: |
Male
medicine.medical_specialty Adolescent Cross-sectional study Azathioprine Inflammatory bowel disease Severity of Illness Index Quality of life Crohn Disease Internal medicine Surveys and Questionnaires medicine Outpatient clinic Humans Child Crohn's disease British Columbia business.industry medicine.disease Ulcerative colitis humanities Cross-Sectional Studies Pediatrics Perinatology and Child Health Quality of Life Colitis Ulcerative Female Analysis of variance business medicine.drug |
| Zdroj: | The Journal of pediatrics. 238 |
| ISSN: | 1097-6833 |
| Popis: | OBJECTIVES To evaluate quality of life (QoL) in a large cohort of pediatric patients with inflammatory bowel disease (IBD) and to identify the clinical factors that influence QoL. STUDY DESIGN This cross-sectional study analyzes a quality improvement initiative in 351 pediatric patients with IBD in British Columbia, Canada using the self-reported Pediatric Quality of Life Inventory (PedsQL) 4.0 generic scale. The questionnaire was completed at outpatient clinic and biologic infusion appointments. Statistical analysis included the t test, ANOVA, and multilinear regressions to evaluate the relationships between clinical factors and QoL. RESULTS Mean (SE) QoL scores (79.95 [0.84]) fell between previously described healthy and chronically ill populations. Disease activity was the most significant predictor of QoL, with patients in remission scoring similar (84.42 [0.87]) to well established healthy norms, and those with moderately or severely active disease having some of the lowest published PedsQL scores (63.13 [3.27]), lower than most other chronic pediatric conditions. Twenty-five patients with moderately or severely active disease at the time of survey completion had follow-up surveys identified 1 year later and had a significant improvement of both their disease activity (P |
| Databáze: | OpenAIRE |
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