Cerebellar Cortex 4–12 Hz Oscillations and Unit Phase Relation in the Awake Rat
| Autor: | Clément Léna, HongYing Gao, Carla Southward, Richard Courtemanche, J. M. Pierre Langlois, Maxime Lévesque |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Cerebellum
cerebellum Cognitive Neuroscience Purkinje cell Neuroscience (miscellaneous) Local field potential lcsh:RC321-571 03 medical and health sciences Cellular and Molecular Neuroscience 0302 clinical medicine Developmental Neuroscience Golgi cell rhythmicity medicine lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry 030304 developmental biology Original Research 0303 health sciences Resting state fMRI Chemistry oscillation Granule cell medicine.anatomical_structure nervous system Cerebral cortex Cerebellar cortex network phase-locking Neuroscience 030217 neurology & neurosurgery |
| Zdroj: | Frontiers in Systems Neuroscience, Vol 14 (2020) Frontiers in Systems Neuroscience |
| ISSN: | 1662-5137 |
| Popis: | Oscillations in the granule cell layer (GCL) of the cerebellar cortex have been related to behavior and could facilitate communication with the cerebral cortex. These local field potential (LFP) oscillations, strong at 4-12 Hz in the rodent cerebellar cortex during awake immobility, should also be an indicator of an underlying influence on the patterns of the cerebellar cortex neuronal firing during rest. To address this hypothesis, cerebellar cortex LFPs and simultaneous single-neuron activity were collected during LFP oscillatory periods in the GCL of awake resting rats. During these oscillatory episodes, different types of units across the GCL and Purkinje cell layers showed variable phase-relation with the oscillatory cycles. Overall, 74% of the Golgi cell firing and 54% of the Purkinje cell simple spike (SS) firing were phase-locked with the oscillations, displaying a clear phase relationship. Despite this tendency, fewer Golgi cells (50%) and Purkinje cell's SSs (25%) showed an oscillatory firing pattern. Oscillatory phase-locked spikes for the Golgi and Purkinje cells occurred towards the peak of the LFP cycle. GCL LFP oscillations had a strong capacity to predict the timing of Golgi cell spiking activity, indicating a strong influence of this oscillatory phenomenon over the GCL. Phase-locking was not as prominent for the Purkinje cell SS firing, indicating a weaker influence over the Purkinje cell layer, yet a similar phase relation. Overall, synaptic activity underlying GCL LFP oscillations likely exert an influence on neuronal population firing patterns in the cerebellar cortex in the awake resting state and could have a preparatory neural network shaping capacity serving as a neural baseline for upcoming cerebellar operations. |
| Databáze: | OpenAIRE |
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