Increases in the Effects of Albendazole on Echinococcus multilocularis Metacestodes by the Dipeptide Methyl Ester (Phe-Phe-OMe)
| Autor: | C Arsac, A F Petavy, S Walbaum, Marie-Elisabeth Sarciron, J. Paris, N. Walchshofer, J Descotes |
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| Rok vydání: | 1997 |
| Předmět: |
Male
Echinococcosis Hepatic Serine Proteinase Inhibitors Cestoda Pharmacology Albendazole Echinococcus multilocularis Gerbil Mice chemistry.chemical_compound Virology parasitic diseases otorhinolaryngologic diseases medicine Animals Anthelmintic Anthelmintics Dipeptide biology Histology Dipeptides biology.organism_classification medicine.disease Echinococcosis Echinococcus Drug Combinations Microscopy Electron Infectious Diseases chemistry Biochemistry Female Parasitology Gerbillinae medicine.drug |
| Zdroj: | The American Journal of Tropical Medicine and Hygiene. 56:226-230 |
| ISSN: | 1476-1645 0002-9637 |
| Popis: | Three months after infection with Echinococcus multilocularis, Mongolian gerbils were given either the dipeptide methyl ester (Phe-Phe-OMe) or a combination of Phe-Phe-OMe plus albendazole to treat alveolar echinococcosis. Each drug was given orally at the daily dose of 50 mg/kg of body weight following various administration regimens. Histologic and ultrastructural studies of parasites recovered from infected gerbil tissues showed that the dipeptide methyl ester increases the effect of albendazole. |
| Databáze: | OpenAIRE |
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