Induction of interferon-stimulated gene expression and antiviral responses require protein deacetylase activity
| Autor: | Michelle Holko, Bryan R.G. Williams, Charles M. Rice, Isabelle Marié, Hao-Ming Chang, David E. Levy, Matthew Paulson |
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| Rok vydání: | 2004 |
| Předmět: |
Transcriptional Activation
Transcription Genetic Hepacivirus Biology Antiviral Agents Histone Deacetylases Vesicular stomatitis Indiana virus Cell Line Transactivation Cytopathogenic Effect Viral Animals Humans RNA Messenger Encephalomyocarditis virus Transcription factor Oligonucleotide Array Sequence Analysis Histone deacetylase 5 Multidisciplinary Protein deacetylase activity Interferon-stimulated gene Acetylation STAT2 Transcription Factor Interferon-Stimulated Gene Factor 3 Biological Sciences Molecular biology Chromatin Interferon-Stimulated Gene Factor 3 gamma Subunit Up-Regulation Cell biology DNA-Binding Proteins Histone Deacetylase Inhibitors STAT1 Transcription Factor Gene Expression Regulation Trans-Activators STAT protein Interferons Histone deacetylase Transcription Factors |
| Zdroj: | Proceedings of the National Academy of Sciences. 101:9578-9583 |
| ISSN: | 1091-6490 0027-8424 |
| DOI: | 10.1073/pnas.0400567101 |
| Popis: | Histone deacetylase (HDAC) activity, commonly correlated with transcriptional repression, was essential for transcriptional induction of IFN-stimulated genes (ISG). Inhibition of HDAC function led to global impairment of ISG expression, with little effect on basal expression. HDAC function was not required for signal transducer and activator of transcription tyrosine phosphorylation, nuclear translocation, or assembly on chromatin, but it was needed for full activity of the signal transducer and activator of transcription transactivation domain. HDAC function was also required for gene induction driven by the IFN regulatory factor 3 transcription factor activated by virus infection, and it was essential for establishment of an antiviral response against Flaviviridae, Rhabdoviridae, and Picornaviridae. Requirement for HDAC function in transcriptional activation may represent a general mechanism for rapid stimulation of ISG transcription. |
| Databáze: | OpenAIRE |
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