High-resolution allele frequencies for NGS based HLA-A, B, C, DQB1 and DRB1 typing of 23,595 bone marrow donors recruited for the Polish central potential unrelated bone marrow donor registry
| Autor: | Jarosław Czerwiński, Anna Bogacz, Klaudia Nestorowicz, Bogusław Tymoniuk, Łukasz Kniżewski, Mariusz Gronkowski, Sylwia Wróblewska-Kabba, Michał Góralski, Michał Kolasiński, Alicja Bukowska, Mateusz Chraplak, Karol Jopek, Małgorzata Dudkiewicz, Mateusz Sowiński, Marek L. Kowalski, Jacek Nowak |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
medicine.medical_treatment Immunology Human leukocyte antigen Hematopoietic stem cell transplantation 03 medical and health sciences 0302 clinical medicine Gene Frequency HLA Antigens medicine Humans Immunology and Allergy Registries Typing Allele Allele frequency Bone Marrow Transplantation business.industry Histocompatibility Testing Haplotype High-Throughput Nucleotide Sequencing General Medicine Tissue Donors HLA-A Genetics Population 030104 developmental biology medicine.anatomical_structure Haplotypes Poland Bone marrow business 030215 immunology |
| Zdroj: | Human Immunology. 81:49-51 |
| ISSN: | 0198-8859 |
| DOI: | 10.1016/j.humimm.2019.12.005 |
| Popis: | Next-generation sequencing (NGS)-based typings of HLA-A, B, C, DQB1 and DRB1 loci were performed from 2018 to 2019 in 23 595 newly recruited or re-typed adult potential bone marrow donors registered in Poltransplant Registry to characterize allele and haplotype frequencies of HLA system for loci important for hematopoietic stem cell transplantation. The donors were recruited for registry and not for any other purpose including controls in a disease association study. The population sample was collected in various regions of Poland including all voivodships. The data regarding the degree of relatedness among individuals in the sample were not collected. Typings were supported by public funds as a part of the Polish National Program for Transplant Medicine Development. HLA frequency data are available in the Allele Frequencies Net Database. |
| Databáze: | OpenAIRE |
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