European polygenic risk score for prediction of breast cancer shows similar performance in Asian women

Autor: Ava Kwong, Anna H. Wu, Kiat Tee Benita Tan, Joanne Ngeow, Anushya Vijayananthan, Kiak Mien Veronique Tan, Qin Wang, Taiki Yamaji, Tsun Leung Chan, Su Ming Tan, Hidemi Ito, Rob M. van Dam, Jaime Seah, Peh Joo Ho, Daniel O. Stram, Jacques Simard, Patrick M. Y. Chan, Chen-Yang Shen, Jingmei Li, Joe Dennis, Sook-Yee Yoon, Ern Yu Tan, Xueling Sim, Min Min Tan, Xiao-Ou Shu, Mei Chee Tai, Antonis C. Antoniou, Keitaro Matsuo, Suniza Jamaris, Chiea Chuen Khor, Jyh Cherng Yu, Sung-Won Kim, Kyriaki Michailidou, Paul D.P. Pharoah, Woon Puay Koh, Ji Yeob Choi, Shivaani Mariapun, Nasim Mavaddat, Geok Hoon Lim, Kartini Rahmat, John J. Spinelli, Swee Ho Lim, Cheng Har Yip, Kristan J. Aronson, Manjeet K. Bolla, Artitaya Lophatananon, Jonathan Tyrer, Motoki Iwasaki, Wei Zheng, Mikael Hartman, Siti Norhidayu Hasan, Nur Aishah Taib, Ching Wan Chan, Daehee Kang, Alison M. Dunning, Kenneth Muir, Weang Kee Ho, Douglas F. Easton, Soo H. Teo, Esther M. John, Sue K. Park, Wei Sean Yong, Allison W. Kurian
Přispěvatelé: Ho, Weang-Kee [0000-0002-8269-7344], Tan, Min-Min [0000-0002-9123-3445], Li, Jingmei [0000-0001-8587-7511], Ho, Peh-Joo [0000-0002-3017-4023], Dennis, Joe [0000-0003-4591-1214], Tyrer, Jonathan P. [0000-0003-3724-4757], Park, Sue K. [0000-0001-5002-9707], Muir, Kenneth [0000-0001-6429-988X], Stram, Daniel O. [0000-0001-7099-9022], Matsuo, Keitaro [0000-0003-1761-6314], Ito, Hidemi [0000-0002-8023-4581], Chan, Ching Wan [0000-0002-9250-1296], Lim, Geok Hoon [0000-0002-5296-3437], Kurian, Allison W. [0000-0002-6175-9470], Khor, Chiea Chuen [0000-0002-1128-4729], Rahmat, Kartini [0000-0001-8513-9076], Sim, Xueling [0000-0002-1233-7642], Pharoah, Paul D. P. [0000-0001-8494-732X], Dunning, Alison M. [0000-0001-6651-7166], Simard, Jacques [0000-0001-6906-3390], Yip, Cheng-Har [0000-0002-6507-9675], Easton, Douglas F. [0000-0003-2444-3247], Teo, Soo-Hwang [0000-0002-0444-590X], Apollo - University of Cambridge Repository, Tyrer, Jonathan P [0000-0003-3724-4757], Park, Sue K [0000-0001-5002-9707], Stram, Daniel O [0000-0001-7099-9022], Kurian, Allison W [0000-0002-6175-9470], Pharoah, Paul DP [0000-0001-8494-732X], Dunning, Alison M [0000-0001-6651-7166], Easton, Douglas F [0000-0003-2444-3247]
Jazyk: angličtina
Rok vydání: 2020
Předmět:
0301 basic medicine
Multifactorial Inheritance
45/43
General Physics and Astronomy
Genome-wide association study
0302 clinical medicine
Breast cancer
Odds Ratio
Medicine
Prospective cohort study
lcsh:Science
Cancer genetics
Cancer
Multidisciplinary
Middle Aged
Prognosis
3. Good health
Europe
030220 oncology & carcinogenesis
language
Female
692/499
631/67
Adult
Risk
Asia
45/61
Science
45/22
Breast Neoplasms
Polymorphism
Single Nucleotide
General Biochemistry
Genetics and Molecular Biology
Article
Europe/epidemiology
03 medical and health sciences
Risk distribution
631/67/68
Humans
Genetic Predisposition to Disease
Malay
Aged
Asia/epidemiology
business.industry
Case-control study
Breast Neoplasms/diagnosis
General Chemistry
Odds ratio
631/67/1347
medicine.disease
language.human_language
030104 developmental biology
Risk factors
Case-Control Studies
Polygenic risk score
lcsh:Q
business
Demography
Genome-Wide Association Study
Zdroj: Nature Communications
Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
Ho, W-K, Tan, M-M, Mavaddat, N, Tai, M-C, Mariapun, S, Li, J, Ho, P-J, Dennis, J, Tyrer, J P, Bolla, M K, Michailidou, K, Wang, Q, Kang, D, Choi, J-Y, Jamaris, S, Shu, X-O, Yoon, S-Y, Park, S K, Kim, S-W, Shen, C-Y, Yu, J-C, Tan, E Y, Chan, P M Y, Muir, K, Lophatananon, A, Wu, A H, Stram, D O, Matsuo, K, Ito, H, Chan, C W, Ngeow, J, Yong, W S, Lim, S H, Lim, G H, Kwong, A, Chan, T L, Tan, S M, Seah, J, John, E M, Kurian, A W, Koh, W-P, Khor, C C, Iwasaki, M, Yamaji, T, Tan, K M V, Tan, K T B, Spinelli, J J, Aronson, K J, Hasan, S N, Rahmat, K, Vijayananthan, A, Sim, X, Pharoah, P D P, Zheng, W, Dunning, A M, Simard, J, van Dam, R M, Yip, C-H, Taib, N A M, Hartman, M, Easton, D F, Teo, S-H & Antoniou, A C 2020, ' European polygenic risk score for prediction of breast cancer shows similar performance in Asian women ', Nature Communications, vol. 11, no. 1, pp. 3833 . https://doi.org/10.1038/s41467-020-17680-w
ISSN: 2041-1723
DOI: 10.1038/s41467-020-17680-w
Popis: Polygenic risk scores (PRS) have been shown to predict breast cancer risk in European women, but their utility in Asian women is unclear. Here we evaluate the best performing PRSs for European-ancestry women using data from 17,262 breast cancer cases and 17,695 controls of Asian ancestry from 13 case-control studies, and 10,255 Chinese women from a prospective cohort (413 incident breast cancers). Compared to women in the middle quintile of the risk distribution, women in the highest 1% of PRS distribution have a ~2.7-fold risk and women in the lowest 1% of PRS distribution has ~0.4-fold risk of developing breast cancer. There is no evidence of heterogeneity in PRS performance in Chinese, Malay and Indian women. A PRS developed for European-ancestry women is also predictive of breast cancer risk in Asian women and can help in developing risk-stratified screening programmes in Asia.
Polygenic risk scores predict the likelihood that an individual will develop a certain cancer, however these are often specific for a given population. Here, the authors show that a risk score developed to assess the risk of breast cancer in European women can also predict risk in Asian populations.
Databáze: OpenAIRE
Externí odkaz: