Cortisol levels among older people with and without depression and dementia
| Autor: | Karin Persson, Anne-Brita Knapskog, Tom Borza, Knut Engedal, Maria Lage Barca, Rannveig Sakshaug Eldholm, Ingvild Saltvedt, Elisabeth Wiken Telenius, Anne Brækhus, Geir Selbæk, Guro Hanevold Bjørkløf |
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| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
medicine.medical_specialty
Health aging Activities of daily living dementia 03 medical and health sciences 0302 clinical medicine mental disorders medicine Dementia Psychiatry Cortisol level Depression (differential diagnoses) Reference group Mini–Mental State Examination 030214 geriatrics medicine.diagnostic_test business.industry Cognition medicine.disease Psychiatry and Mental health Clinical Psychology neuroendocrinology depression Geriatrics and Gerontology business Gerontology 030217 neurology & neurosurgery |
| Zdroj: | International psychogeriatrics |
| ISSN: | 1041-6102 |
| Popis: | Cortisol dysregulation has been reported in dementia and depression. Cortisol levels and its associates were investigated among older people living at home and in nursing homes, in a cross-sectional study. A sample of 650 older people, from the community (home and nursing homes) and specialized care (memory clinics and old age psychiatry wards), mean age 76.8 (SD = 10.3) (dementia n = 319, depression, n = 154, dementia plus depression n = 53, and reference group n = 124), was included. Assessment included the Mini Mental State Examination (MMSE), Cornell scale for depression in dementia, activities of daily living scales, and salivary cortisol. Number of drugs was registered. The results showed that the cortisol ratio was highest among patients with dementia and co-morbid depression in comparison to those with either depression or dementia and the reference group. Characteristics significantly associated with cortisol levels were higher MMSE score (in patients with dementia and co-morbid depression), male gender (in people with dementia), and number of medications (in the reference group). We conclude that the cortisol ratio was highest among patients with dementia and co-morbid depression in comparison to those with either depression or dementia and the reference group. The association of cortisol level with MMSE score among patients with dementia and depression could further indicate that increased stress is related to cognitive function. © 2018. This is the authors' accepted and refereed manuscript to the article. Locked until 17.6.2019 due to copyright restrictions. The final authenticated version is available online at: https://doi.org/10.1017/S1041610218001199 |
| Databáze: | OpenAIRE |
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