Pattern differences between newborn and adult rats in cisplatin-induced hepatorenal toxicity
| Autor: | Pietro Maria Chagas, Cristina W. Nogueira, Bruna da Cruz Weber Fulco, Juliano Ten Kathen Jung, Gilson Zeni, Caroline B. Quines |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Male
0301 basic medicine medicine.medical_specialty NF-E2-Related Factor 2 Antineoplastic Agents Kidney Toxicology medicine.disease_cause Nephrotoxicity 03 medical and health sciences 0302 clinical medicine Internal medicine medicine Animals Aspartate Aminotransferases Sulfhydryl Compounds Rats Wistar Adverse effect Cisplatin Kelch-Like ECH-Associated Protein 1 Superoxide Dismutase business.industry Alanine Transaminase Porphobilinogen Synthase General Medicine Catalase Rats Oxidative Stress 030104 developmental biology medicine.anatomical_structure NPSH Endocrinology Animals Newborn Liver Apoptosis 030220 oncology & carcinogenesis Toxicity Female Sodium-Potassium-Exchanging ATPase business Oxidative stress medicine.drug |
| Zdroj: | Chemico-Biological Interactions. 294:65-73 |
| ISSN: | 0009-2797 |
| DOI: | 10.1016/j.cbi.2018.08.011 |
| Popis: | Although cisplatin (CIS) has been associated with serious adverse effects, such as hepatotoxicity and nephrotoxicity in adult rats, there is few reports on its use in newborn rats. The aim of this study was to evaluate acute toxic effects of CIS in newborn rats. Adult and newborn Wistar rats received CIS by the i. p. route, at the dose of 5 or 10 mg/kg. After 24 h of treatment, blood, kidney, and liver were excised from the animals and parameters of renal and hepatic functions, oxidative stress markers were determined. Acute administration of CIS caused an increase of AST activity and urea levels, suggesting hepatorenal toxicity in newborn and adult rats. However, the pattern and intensity of damage was different between ages and tissues. Newborn rats showed more pronouncedly oxidative stress damage, characterized by an increase in reactive species and protein carbonyl levels, lower NPSH content and highest inhibition in δ-ALA-D and CAT activities. Besides that, it was observed a faster molecular response in protein levels involved with apoptosis and oxidative stress response; whereas in the beginning the damage was less severe in the kidney than in the liver of adult rats. Thus, the present study shows that there are body response differences between adult and newborn rats to CIS acute exposure being that newborn rats are more susceptible than adults. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect