Nutritional factors and thalassaemia major
| Autor: | Prasong Tienboon, S Tovanabutra, P Leelapat, S Nimsakul, G J Fuchs, S Linpisarn, Marianne DeWier, Robert M. Suskind, V Tubtong |
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| Rok vydání: | 1996 |
| Předmět: |
Male
Pediatrics medicine.medical_specialty Nutritional Status chemistry.chemical_compound medicine Humans Insulin-Like Growth Factor I Wasting Growth Disorders Thalassaemia major Anthropometry business.industry Body Weight beta-Thalassemia Infant Nutritional status medicine.disease Dietary Fats Body Height Nutrition Disorders Malnutrition Regimen chemistry Child Preschool Pediatrics Perinatology and Child Health Female medicine.symptom alpha-Tocopherol business Weight gain Research Article |
| Zdroj: | Archives of disease in childhood. 74(3) |
| ISSN: | 1468-2044 |
| Popis: | Abnormal growth is a common feature of thalassaemia major in children. In an attempt to determine whether it has a nutritional cause, 12 children aged 1 to 3 years with thalassaemia major were studied under metabolic ward conditions. Nutritional status was assessed by anthropometry and biochemistry before and after an intensive nutrition regimen. Five children had wasting or stunting on admission. As a result of the nutrition intervention, mean weight for height improved significantly. The mean height increase of 0.4 cm after one month was not significant. Plasma zinc, depressed in half the children on admission, improved, as did alpha tocopherol, while copper decreased. Plasma insulin-like growth factor-I also increased commensurate with improved growth. Fat absorption was normal in all children. Undernutrition is an important cause of associated growth disturbances in children with thalassaemia major. Malnutrition was primarily caused by inadequate nutrient intake, as indicated by the capacity to gain weight appropriately when provided with nutrition support, and by the absence of intestinal malabsorption. While long term studies are required to determine if nutritional support will prevent stunting, these results underscore its central role in preventing nutritional deficiencies and in promoting normal growth in thalassaemic children. |
| Databáze: | OpenAIRE |
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