The effects of ginsenosides on platelet aggregation and vascular intima in the treatment of cardiovascular diseases: From molecular mechanisms to clinical applications
| Autor: | Yi-Fan Fang, Jia-Li Jiang, Bing-Chen Zhang, Meng-Die Yin, Fang Yang, Bang-Yue Luo, Jingwei Shao, Ruirui Zhao |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Blood Platelets Platelet aggregation Ginsenosides Platelet Aggregation Abnormal platelet aggregation Biological Availability Vascular Remodeling Bioinformatics Muscle Smooth Vascular 03 medical and health sciences chemistry.chemical_compound Ginseng Structure-Activity Relationship 0302 clinical medicine Neointima Antithrombotic Medicine Animals Humans Pharmacology Signal Pathways Molecular Structure business.industry Cvd prevention Cardiovascular Agents Management strategy 030104 developmental biology chemistry Ginsenoside Cardiovascular Diseases 030220 oncology & carcinogenesis business Platelet Aggregation Inhibitors Signal Transduction |
| Zdroj: | Pharmacological research. 159 |
| ISSN: | 1096-1186 |
| Popis: | Thrombosis initiated by abnormal platelet aggregation is a pivotal pathological event that precedes most cases of cardiovascular diseases (CVD). Recently, growing evidence indicates that platelet could be a potential target for CVD prevention. However, as the conventional antithrombotic management strategy, applications of current antiplatelet agents are somewhat limited by their various side effects, such as bleeding risk and drug resistance. Hence, efforts have been made to search for agents as complementary therapies. Ginsenoside, the principal active component extracted from Panax ginseng, has gained much attention for its regulations on multiple crucial events of platelet aggregation. From structural characteristics to clinical applications, this review anatomized the intrinsic structure-function relationship of antiplatelet potency of ginsenosides, and the involved signal pathways were specifically summarized. Additionally, the emphasis was placed on clinical studies that investigate the antithrombotic efficacy of ginsenosides in the treatment of CVD. Further, a broad overview of approaches for improving the bioavailability of ginsenosides was concluded. Limitations and prospects of current studies were also discussed. This study may provide some new insights into the systematic understanding of ginsenosides in CVD treatment and lay a foundation for future research. |
| Databáze: | OpenAIRE |
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